The synthesis of poly(hydroxamic acid) from poly(acrylamide)

A. J. Domb, E. G. Cravalho, R. Langer

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57 Scopus citations


Poly(hydroxamic acid) in gel or water soluble from was prepared from the reaction of poly(acrylamide) and hydroxylamine in basic aqueous solution (pH > 12) at room temperature. The polymers were composed of 70% hydroxamic acid groups, less than 5% carboxylic acid groups, and 25% unreacted amide groups. The polymers exhibited high affinity to iron(III) and copper(II) in the pH range of 1 to 5 with a high binding rate. A binding of 3 mmol/g for both metals was achieved. Preliminary tests demonstrated the urease inhibitory activity of both linear and crosslinked poly(hydroxamic acids).

Original languageEnglish
Pages (from-to)2623-2630
Number of pages8
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Issue number10
StatePublished - Sep 1988
Externally publishedYes


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