The Synthesis of Nucleoside 2′,3′-Cyclic Monophosphate Analogs with Regio- and Stereospecificity

Molhm Nassir; Abed Saady; Natalie Pariene Cohen; Bilha Fischer

doi:10.1002/cpz1.287

The Synthesis of Nucleoside 2′,3′-Cyclic Monophosphate Analogs with Regio- and Stereospecificity

Molhm Nassir, Abed Saady, Natalie Pariene Cohen, Bilha Fischer

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

This article presents a new method for the rapid, stereoselective and regioselective synthesis of nucleoside 2′,3′-O,O-phosphorothioate and 2′,3′-O,O-phosphoroselenoate molecules. The method avoids the use of protection groups, chiral reagents, and chiral metal catalysts, as well as complicated chiral separations. This synthetic method has been applied successfully to all of the natural nucleosides.

Original language	English
Article number	e287
Journal	Current Protocols
Volume	1
Issue number	11
DOIs	https://doi.org/10.1002/cpz1.287
State	Published - Nov 2021

Bibliographical note

Publisher Copyright:
© 2021 Wiley Periodicals LLC

Keywords

DBU
cyclic phosphorothioate
nucleoside
nucleotides
thiophosphate

Access to Document

10.1002/cpz1.287

Cite this

@article{ce469d5e9ed545b8bd90db9009b6858c,

title = "The Synthesis of Nucleoside 2′,3′-Cyclic Monophosphate Analogs with Regio- and Stereospecificity",

abstract = "This article presents a new method for the rapid, stereoselective and regioselective synthesis of nucleoside 2′,3′-O,O-phosphorothioate and 2′,3′-O,O-phosphoroselenoate molecules. The method avoids the use of protection groups, chiral reagents, and chiral metal catalysts, as well as complicated chiral separations. This synthetic method has been applied successfully to all of the natural nucleosides.",

keywords = "DBU, cyclic phosphorothioate, nucleoside, nucleotides, thiophosphate",

author = "Molhm Nassir and Abed Saady and Cohen, {Natalie Pariene} and Bilha Fischer",

note = "Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC",

year = "2021",

month = nov,

doi = "10.1002/cpz1.287",

language = "אנגלית",

volume = "1",

journal = "Current Protocols",

issn = "2691-1299",

publisher = "John Wiley & Sons Inc.",

number = "11",

}

TY - JOUR

T1 - The Synthesis of Nucleoside 2′,3′-Cyclic Monophosphate Analogs with Regio- and Stereospecificity

AU - Nassir, Molhm

AU - Saady, Abed

AU - Cohen, Natalie Pariene

AU - Fischer, Bilha

PY - 2021/11

Y1 - 2021/11

N2 - This article presents a new method for the rapid, stereoselective and regioselective synthesis of nucleoside 2′,3′-O,O-phosphorothioate and 2′,3′-O,O-phosphoroselenoate molecules. The method avoids the use of protection groups, chiral reagents, and chiral metal catalysts, as well as complicated chiral separations. This synthetic method has been applied successfully to all of the natural nucleosides.

AB - This article presents a new method for the rapid, stereoselective and regioselective synthesis of nucleoside 2′,3′-O,O-phosphorothioate and 2′,3′-O,O-phosphoroselenoate molecules. The method avoids the use of protection groups, chiral reagents, and chiral metal catalysts, as well as complicated chiral separations. This synthetic method has been applied successfully to all of the natural nucleosides.

KW - DBU

KW - cyclic phosphorothioate

KW - nucleoside

KW - nucleotides

KW - thiophosphate

UR - http://www.scopus.com/inward/record.url?scp=85120358059&partnerID=8YFLogxK

U2 - 10.1002/cpz1.287

DO - 10.1002/cpz1.287

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 34826354

AN - SCOPUS:85120358059

SN - 2691-1299

VL - 1

JO - Current Protocols

JF - Current Protocols

IS - 11

M1 - e287

ER -

The Synthesis of Nucleoside 2′,3′-Cyclic Monophosphate Analogs with Regio- and Stereospecificity

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this