Abstract
T cell activation is predicated on the interaction between the T cell receptor and peptide-major histocompatibility (pMHC) ligands. The factors that determine the stimulatory potency of a pMHC molecule remain unclear. We describe results showing that a peptide exhibiting many hallmarks of a weak agonist stimulates T cells to proliferate more than the wild-type agonist ligand. An in silico approach suggested that the inability to form the central supramolecular activation cluster (cSMAC) could underlie the increased proliferation. This conclusion was supported by experiments that showed that enhancing cSMAC formation reduced stimulatory capacity of the weak peptide. Our studies highlight the fact that a complex interplay of factors determines the quality of a T cell antigen.
Original language | English |
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Pages (from-to) | 345-355 |
Number of pages | 11 |
Journal | Immunity |
Volume | 26 |
Issue number | 3 |
DOIs | |
State | Published - 23 Mar 2007 |
Externally published | Yes |
Bibliographical note
Funding Information:We thank M. Dustin for fruitful discussions. This research is supported by the NIH (grants AI034094, AI057966, and AI071195-01).
Funding
We thank M. Dustin for fruitful discussions. This research is supported by the NIH (grants AI034094, AI057966, and AI071195-01).
Funders | Funder number |
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National Institutes of Health | AI071195-01, AI057966 |
National Institute of Allergy and Infectious Diseases | R01AI034094 |
Keywords
- CELLIMMUNO
- MOLIMMUNO
- SIGNALING