The Significance of Omega-3/Omega-6 Ratio to Aging Brain Functions

S Yehuda

Research output: Contribution to journalArticlepeer-review


In addition to a gradual loss of neurons in various brain regions, major biochemical changes in the aging brain affect the neuronal membrane that is the "site of action" for many essential functions learning and memory, sleep, pain threshold, and thermoregulation. Normal physiological functioning includes the transmission of axonal information, regulation of membrane-bound enzymes, control of ionic channels and various receptors. All are highly dependent on membrane fluidity, where rigidity is increased during aging. The significantly higher level of cholesterol in aging neuronal membrane, the slow rate of cholesterol turnover, and the decreased level of total PUFA may result from poor passage rate via the blood-brain barrier, or from a decreased rate of incomrporation into the membrane. Administration of a ratio of 1: 4 of omega 3/omega 6 PUFA may improve the neuronal membrane functions and behavior of the aging brain
Original languageAmerican English
Pages (from-to)31-34
Number of pages4
JournalAgro Food Industry Hi-Tech
Issue number2
StatePublished - 2013


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