The Significance of Atrial Fibrillation in Patients With Transient Global Amnesia

Naaem Simaan, Asaf Honig, Andrei Filioglo, Molad Jeremy, Ronen R. Leker

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2 Scopus citations


Background and Purpose: The etiology of transient global amnesia (TGA) remains unclear in a large subset of patients. We aimed to determine the clinical and radiological characteristics of TGA-patients with suspected acute micro-embolic stroke on diffusion-weighted imaging (DWI). Methods: TGA-patients that had new DWI hippocampal lesions (DWI+) were compared to DWI negative TGA-patients (DWI–). Demographics, risk factors, clinical data, radiological data, and mortality were analyzed. Results: Out of 83 patients diagnosed with TGA, 56 (65%) underwent MRI during the acute hospitalization and 26 (46%) had new hippocampal DWI lesions. DWI+ patients more often had a history of atrial fibrillation (AF, 26 vs. 7%, p = 0.04) but the frequency of other risk factors did not differ. None of the patients died, however, two DWI+ patients had subsequent stroke during a 2-year follow up and both had AF. In contrast, none of the DWI- patients had recurrent events. Conclusion: AF is common among DWI+ TGA-patients. The presence of AF in patients with TGA could suggest an increased risk of subsequent stroke.

Original languageEnglish
Article number830727
JournalFrontiers in Neurology
StatePublished - 7 Mar 2022

Bibliographical note

Publisher Copyright:
Copyright © 2022 Simaan, Honig, Filioglo, Jeremy and Leker.


  • atrial fibrillation
  • diffusion-weighted imaging
  • hippocampal lesions
  • micro-embolic stroke
  • transient global amnesia


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