The role of T-lymphocyte subpopulations in acute myocardial infarction

Arnon Blum, Shay Yeganeh

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


T lymphocytes have the potential to affect atherosclerosis at different stages of the process. They play an active role in acute myocardial infarction (AMI) and myocardial damage, and may affect the clinical outcome of patients with coronary artery disease. CD40 ligand expression on T lymphocytes promotes the expression of matrix-degrading enzymes in vascular smooth muscle cells and may thus establish a new pathway of immune-mediated destabilization of the human atheroma. The major class of T lymphocytes present in atherosclerotic lesions is CD4+. CD4+ cells differentiate into Th1 and Th2 lineage in response to the local milieu of cytokines. Much of the emphasis in atherosclerosis research is focused on the role of Th1 type responses.

Original languageEnglish
Pages (from-to)407-410
Number of pages4
JournalEuropean Journal of Internal Medicine
Issue number7
StatePublished - Nov 2003
Externally publishedYes


  • Atherosclerosis
  • CD4+
  • CD8+
  • Lymphocytes
  • Th1
  • Th2


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