The Role of Response Inhibition in Medicated and Unmedicated Obsessive-Compulsive Disorder Patients: Evidence from the Stop-Signal Task

Eyal Kalanthroff; Tobias Teichert; Michael G. Wheaton; Marcia B. Kimeldorf; Omer Linkovski; Susanne E. Ahmari; Abby J. Fyer; Franklin R. Schneier; Gideon E. Anholt; H. Blair Simpson

doi:10.1002/da.22492

The Role of Response Inhibition in Medicated and Unmedicated Obsessive-Compulsive Disorder Patients: Evidence from the Stop-Signal Task

Eyal Kalanthroff, Tobias Teichert, Michael G. Wheaton, Marcia B. Kimeldorf, Omer Linkovski, Susanne E. Ahmari, Abby J. Fyer, Franklin R. Schneier, Gideon E. Anholt, H. Blair Simpson

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Background: Numerous studies have investigated response inhibition (RI) in obsessive-compulsive disorder (OCD), with many reporting that OCD patients demonstrate deficits in RI as compared to controls. However, reported effect sizes tend to be modest and results have been inconsistent, with some studies finding intact RI in OCD. To date, no study has examined the effect of medications on RI in OCD patients. Methods: We analyzed results from a stop-signal task to probe RI in 65 OCD patients (32 of whom were medicated) and 58 healthy controls (HCs). Results: There was no statistically significant difference in stop-signal reaction time between the OCD group and the HC group, or between the medicated and unmedicated OCD patients. However, variability was significantly greater in the medicated OCD group compared to the unmedicated group. Conclusions: These results indicate that some samples of OCD patients do not have deficits in RI, making it unlikely that deficient RI underlies repetitive behaviors in all OCD patients. Future research is needed to fully elucidate the impact of medication use on stop-signal performance. Implications for future research on the cognitive processes underlying repetitive thoughts and behaviors are discussed.

Original language	English
Pages (from-to)	301-306
Number of pages	6
Journal	Depression and Anxiety
Volume	34
Issue number	3
DOIs	https://doi.org/10.1002/da.22492
State	Published - 1 Mar 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016 Wiley Periodicals, Inc.

Funding

This study was supported by the National Institute of Mental Health (R01MH091694 [PIs: H.B.S., F.R.S., and A.J.F.], K24MH091555 [PI: H.B.S.], the New York State Office of Mental Hygiene, and donors to the New York-Presbyterian Hospital Youth Anxiety Center. Dr. Kalanthroff is supported by the Rothschild foundation, the Molberger Scholar award, and by The Israel Science Foundation (Grant No. 79/15).

Funders	Funder number
New York State Office of Mental Hygiene
Rothschild Foundation
National Institute of Mental Health	K24MH091555, R01MH091694
Israel Science Foundation	79/15

Keywords

attention
cognitive manifestations
executive function
psychopathology
stop signal

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/da.22492

Cite this

Kalanthroff, E., Teichert, T., Wheaton, M. G., Kimeldorf, M. B., Linkovski, O., Ahmari, S. E., Fyer, A. J., Schneier, F. R., Anholt, G. E., & Simpson, H. B. (2017). The Role of Response Inhibition in Medicated and Unmedicated Obsessive-Compulsive Disorder Patients: Evidence from the Stop-Signal Task. Depression and Anxiety, 34(3), 301-306. https://doi.org/10.1002/da.22492

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abstract = "Background: Numerous studies have investigated response inhibition (RI) in obsessive-compulsive disorder (OCD), with many reporting that OCD patients demonstrate deficits in RI as compared to controls. However, reported effect sizes tend to be modest and results have been inconsistent, with some studies finding intact RI in OCD. To date, no study has examined the effect of medications on RI in OCD patients. Methods: We analyzed results from a stop-signal task to probe RI in 65 OCD patients (32 of whom were medicated) and 58 healthy controls (HCs). Results: There was no statistically significant difference in stop-signal reaction time between the OCD group and the HC group, or between the medicated and unmedicated OCD patients. However, variability was significantly greater in the medicated OCD group compared to the unmedicated group. Conclusions: These results indicate that some samples of OCD patients do not have deficits in RI, making it unlikely that deficient RI underlies repetitive behaviors in all OCD patients. Future research is needed to fully elucidate the impact of medication use on stop-signal performance. Implications for future research on the cognitive processes underlying repetitive thoughts and behaviors are discussed.",

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The Role of Response Inhibition in Medicated and Unmedicated Obsessive-Compulsive Disorder Patients: Evidence from the Stop-Signal Task

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

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