Abstract
The biological basis of human aging remains one of the greatest unanswered scientific questions. Increasing evidence, however, points to a role for alterations in mitochondrial function as a potential central regulator of the aging process. Here, we focus primarily on three aspects of mitochondrial biology that link this ancient organelle to how and why we age. In particular, we discuss the role of mitochondria in regulating the innate immune system, the mechanisms linking mitochondrial quality control to age-dependent pathology, and the possibility that mitochondrial-to-nuclear signaling might regulate the rate of aging.
| Original language | English |
|---|---|
| Pages (from-to) | 3662-3670 |
| Number of pages | 9 |
| Journal | Journal of Clinical Investigation |
| Volume | 128 |
| Issue number | 9 |
| DOIs | |
| State | Published - 31 Aug 2018 |
Bibliographical note
Publisher Copyright:© 2018 American Society for Clinical Investigation. All rights reserved.
Funding
This work was supported by funds from the Leducq Foundation and the Progeria Research Foundation.
| Funders |
|---|
| Progeria Research Foundation |
| Fondation Leducq |
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