The role of chromatin dynamics under global warming response in the symbiotic coral model Aiptasia

Eviatar Weizman; Oren Levy

doi:10.1038/s42003-019-0543-y

The role of chromatin dynamics under global warming response in the symbiotic coral model Aiptasia

Eviatar Weizman, Oren Levy

The Mina and Everard Goodman Faculty of Life Sciences

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Extreme weather events frequency and scale are altered due to climate change. Symbiosis between corals and their endosymbiotic-dinoflagellates (Symbiodinium) is susceptible to these events and can lead to what is known as bleaching. However, there is evidence for coral adaptive plasticity in the role of epigenetic that have acclimated to high-temperature environments. We have implemented ATAC-seq and RNA-seq to study the cnidarian-dinoflagellate model Exaptasia pallida (Aiptasia) and expose the role of chromatin-dynamics in response to thermal-stress. We have identified 1309 genomic sites that change their accessibility in response to thermal changes. Moreover, apo-symbiotic Aiptasia accessible sites were enriched with NFAT, ATF4, GATA3, SOX14, and PAX3 motifs and expressed genes related to immunological pathways. Symbiotic Aiptasia accessible sites were enriched with NKx3-1, HNF4A, IRF4 motifs and expressed genes related to oxidative-stress pathways. Our work opens a new path towards understanding thermal-stress gene regulation in association with gene activity and chromatin-dynamics.

Original language	English
Article number	282
Journal	Communications Biology
Volume	2
Issue number	1
DOIs	https://doi.org/10.1038/s42003-019-0543-y
State	Published - 1 Dec 2019

Bibliographical note

Publisher Copyright:
© 2019, The Author(s).

Funding

The research leading to this paper has received funding from the Moore Foundation, “Unwinding the Circadian Clock in a Sea Anemone” (Grant #4598) to A.T & O.L. and funding from the Israeli Science Foundation (ISF), Grant #580/19 to O.L. We would like to thank Ms. Adi Zweifler and Dr. Noa Simon Blecher for their help with Aiptasia pallida cultures and assistance. We also would like to thank The Interuniversity Institute for Marine Sciences in Eilat (IUI) for the support in this research. This study represents partial fulfillment of the requirements for a Ph.D. thesis for E. Weizman at Faculty of Life Sciences Bar-Ilan University, Israel.

Funders	Funder number
Israeli Science Foundation	580/19
Gordon and Betty Moore Foundation	4598

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s42003-019-0543-y

Cite this

@article{43398dc6e4594a7987d669c11f5361e4,

title = "The role of chromatin dynamics under global warming response in the symbiotic coral model Aiptasia",

abstract = "Extreme weather events frequency and scale are altered due to climate change. Symbiosis between corals and their endosymbiotic-dinoflagellates (Symbiodinium) is susceptible to these events and can lead to what is known as bleaching. However, there is evidence for coral adaptive plasticity in the role of epigenetic that have acclimated to high-temperature environments. We have implemented ATAC-seq and RNA-seq to study the cnidarian-dinoflagellate model Exaptasia pallida (Aiptasia) and expose the role of chromatin-dynamics in response to thermal-stress. We have identified 1309 genomic sites that change their accessibility in response to thermal changes. Moreover, apo-symbiotic Aiptasia accessible sites were enriched with NFAT, ATF4, GATA3, SOX14, and PAX3 motifs and expressed genes related to immunological pathways. Symbiotic Aiptasia accessible sites were enriched with NKx3-1, HNF4A, IRF4 motifs and expressed genes related to oxidative-stress pathways. Our work opens a new path towards understanding thermal-stress gene regulation in association with gene activity and chromatin-dynamics.",

author = "Eviatar Weizman and Oren Levy",

note = "Publisher Copyright: {\textcopyright} 2019, The Author(s).",

year = "2019",

month = dec,

day = "1",

doi = "10.1038/s42003-019-0543-y",

language = "אנגלית",

volume = "2",

journal = "Communications Biology",

issn = "2399-3642",

publisher = "Springer Nature",

number = "1",

}

TY - JOUR

T1 - The role of chromatin dynamics under global warming response in the symbiotic coral model Aiptasia

AU - Weizman, Eviatar

AU - Levy, Oren

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Extreme weather events frequency and scale are altered due to climate change. Symbiosis between corals and their endosymbiotic-dinoflagellates (Symbiodinium) is susceptible to these events and can lead to what is known as bleaching. However, there is evidence for coral adaptive plasticity in the role of epigenetic that have acclimated to high-temperature environments. We have implemented ATAC-seq and RNA-seq to study the cnidarian-dinoflagellate model Exaptasia pallida (Aiptasia) and expose the role of chromatin-dynamics in response to thermal-stress. We have identified 1309 genomic sites that change their accessibility in response to thermal changes. Moreover, apo-symbiotic Aiptasia accessible sites were enriched with NFAT, ATF4, GATA3, SOX14, and PAX3 motifs and expressed genes related to immunological pathways. Symbiotic Aiptasia accessible sites were enriched with NKx3-1, HNF4A, IRF4 motifs and expressed genes related to oxidative-stress pathways. Our work opens a new path towards understanding thermal-stress gene regulation in association with gene activity and chromatin-dynamics.

AB - Extreme weather events frequency and scale are altered due to climate change. Symbiosis between corals and their endosymbiotic-dinoflagellates (Symbiodinium) is susceptible to these events and can lead to what is known as bleaching. However, there is evidence for coral adaptive plasticity in the role of epigenetic that have acclimated to high-temperature environments. We have implemented ATAC-seq and RNA-seq to study the cnidarian-dinoflagellate model Exaptasia pallida (Aiptasia) and expose the role of chromatin-dynamics in response to thermal-stress. We have identified 1309 genomic sites that change their accessibility in response to thermal changes. Moreover, apo-symbiotic Aiptasia accessible sites were enriched with NFAT, ATF4, GATA3, SOX14, and PAX3 motifs and expressed genes related to immunological pathways. Symbiotic Aiptasia accessible sites were enriched with NKx3-1, HNF4A, IRF4 motifs and expressed genes related to oxidative-stress pathways. Our work opens a new path towards understanding thermal-stress gene regulation in association with gene activity and chromatin-dynamics.

UR - http://www.scopus.com/inward/record.url?scp=85071155233&partnerID=8YFLogxK

U2 - 10.1038/s42003-019-0543-y

DO - 10.1038/s42003-019-0543-y

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 31396562

SN - 2399-3642

VL - 2

JO - Communications Biology

JF - Communications Biology

IS - 1

M1 - 282

ER -

The role of chromatin dynamics under global warming response in the symbiotic coral model Aiptasia

Abstract

Bibliographical note

Funding

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this