The role of B cells and autoantibodies in neuropsychiatric lupus

Jing Wen, Ariel D. Stock, Samantha A. Chalmers, Chaim Putterman

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

The central nervous system manifestations of SLE (neuropsychiatric lupus, NPSLE) occur frequently, though are often difficult to diagnose and treat. Symptoms of NPSLE can be quite diverse, including chronic cognitive and emotional manifestations, as well as acute presentations, such as stroke and seizures. Although the pathogenesis of NPSLE has yet to be well characterized, B-cell mediated damage is believed to be an important contributor. B-cells and autoantibodies may traverse the blood brain barrier promoting an inflammatory environment consisting of glia activation, neurodegeneration, and consequent averse behavioral outcomes. This review will evaluate the various suggested roles of B-cells and autoantibodies in NPSLE, as well as therapeutic modalities targeting these pathogenic mediators.

Original languageEnglish
Pages (from-to)890-895
Number of pages6
JournalAutoimmunity Reviews
Volume15
Issue number9
DOIs
StatePublished - 1 Sep 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 Elsevier B.V.

Funding

These studies were supported by a research grant from the NIH ( AR065594 ) to C. Putterman.

FundersFunder number
National Institutes of HealthAR065594
National Institute of General Medical SciencesT32GM007288

    Keywords

    • Autoantibodies
    • B cells
    • Neuropsychiatric lupus
    • SLE

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