The role of B cells and autoantibodies in neuropsychiatric lupus

Jing Wen, Ariel D. Stock, Samantha A. Chalmers, Chaim Putterman

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


The central nervous system manifestations of SLE (neuropsychiatric lupus, NPSLE) occur frequently, though are often difficult to diagnose and treat. Symptoms of NPSLE can be quite diverse, including chronic cognitive and emotional manifestations, as well as acute presentations, such as stroke and seizures. Although the pathogenesis of NPSLE has yet to be well characterized, B-cell mediated damage is believed to be an important contributor. B-cells and autoantibodies may traverse the blood brain barrier promoting an inflammatory environment consisting of glia activation, neurodegeneration, and consequent averse behavioral outcomes. This review will evaluate the various suggested roles of B-cells and autoantibodies in NPSLE, as well as therapeutic modalities targeting these pathogenic mediators.

Original languageEnglish
Pages (from-to)890-895
Number of pages6
JournalAutoimmunity Reviews
Issue number9
StatePublished - 1 Sep 2016
Externally publishedYes

Bibliographical note

Funding Information:
These studies were supported by a research grant from the NIH ( AR065594 ) to C. Putterman.

Publisher Copyright:
© 2016 Elsevier B.V.


  • Autoantibodies
  • B cells
  • Neuropsychiatric lupus
  • SLE


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