Kidney disease, or lupus nephritis, is the organ involvement that is most closely associated with specific autoantibodies in patients with SLE. The concept of anti-DNA antibodies being instrumental in the pathogenesis of lupus nephritis emerged ~50 years ago, and has been a topic of debate ever since. This article focuses on the description of the renal sub-cellular targets of nephritogenic autoantibodies and offers a counter-point opinion to the article by Pedersen et al. In addition, we provide an overview of some of the mechanisms by which anti-DNA antibodies bind to their renal targets and the pathogenic relevance to clinical nephritis.
|Number of pages||5|
|Journal||Seminars in Nephrology|
|State||Published - 2015|
Bibliographical noteFunding Information:
Financial support: Supported by the National Institutes of Health (R01 AR048692 to C.P.).
© 2015 Elsevier Inc.
- Anti-DNA antibodies
- Lupus nephritis
- Nephritogenic antibodies