Abstract
Kidney disease, or lupus nephritis, is the organ involvement that is most closely associated with specific autoantibodies in patients with SLE. The concept of anti-DNA antibodies being instrumental in the pathogenesis of lupus nephritis emerged ~50 years ago, and has been a topic of debate ever since. This article focuses on the description of the renal sub-cellular targets of nephritogenic autoantibodies and offers a counter-point opinion to the article by Pedersen et al. In addition, we provide an overview of some of the mechanisms by which anti-DNA antibodies bind to their renal targets and the pathogenic relevance to clinical nephritis.
Original language | English |
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Pages (from-to) | 439-443 |
Number of pages | 5 |
Journal | Seminars in Nephrology |
Volume | 35 |
Issue number | 5 |
DOIs | |
State | Published - 2015 |
Externally published | Yes |
Bibliographical note
Funding Information:Financial support: Supported by the National Institutes of Health (R01 AR048692 to C.P.).
Publisher Copyright:
© 2015 Elsevier Inc.
Keywords
- Anti-DNA antibodies
- Cross-reactivity
- Lupus nephritis
- Nephritogenic antibodies