The Role of Anti-DNA Antibodies in the Development of Lupus Nephritis: A Complementary, or Alternative, Viewpoint?

Beatrice Goilav; Chaim Putterman

doi:10.1016/j.semnephrol.2015.08.005

The Role of Anti-DNA Antibodies in the Development of Lupus Nephritis: A Complementary, or Alternative, Viewpoint?

Beatrice Goilav, Chaim Putterman

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Kidney disease, or lupus nephritis, is the organ involvement that is most closely associated with specific autoantibodies in patients with SLE. The concept of anti-DNA antibodies being instrumental in the pathogenesis of lupus nephritis emerged ~50 years ago, and has been a topic of debate ever since. This article focuses on the description of the renal sub-cellular targets of nephritogenic autoantibodies and offers a counter-point opinion to the article by Pedersen et al. In addition, we provide an overview of some of the mechanisms by which anti-DNA antibodies bind to their renal targets and the pathogenic relevance to clinical nephritis.

Original language	English
Pages (from-to)	439-443
Number of pages	5
Journal	Seminars in Nephrology
Volume	35
Issue number	5
DOIs	https://doi.org/10.1016/j.semnephrol.2015.08.005
State	Published - 2015
Externally published	Yes

Bibliographical note

Funding Information:
Financial support: Supported by the National Institutes of Health (R01 AR048692 to C.P.).

Publisher Copyright:
© 2015 Elsevier Inc.

Keywords

Anti-DNA antibodies
Cross-reactivity
Lupus nephritis
Nephritogenic antibodies

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10.1016/j.semnephrol.2015.08.005

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title = "The Role of Anti-DNA Antibodies in the Development of Lupus Nephritis: A Complementary, or Alternative, Viewpoint?",

abstract = "Kidney disease, or lupus nephritis, is the organ involvement that is most closely associated with specific autoantibodies in patients with SLE. The concept of anti-DNA antibodies being instrumental in the pathogenesis of lupus nephritis emerged ~50 years ago, and has been a topic of debate ever since. This article focuses on the description of the renal sub-cellular targets of nephritogenic autoantibodies and offers a counter-point opinion to the article by Pedersen et al. In addition, we provide an overview of some of the mechanisms by which anti-DNA antibodies bind to their renal targets and the pathogenic relevance to clinical nephritis.",

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AB - Kidney disease, or lupus nephritis, is the organ involvement that is most closely associated with specific autoantibodies in patients with SLE. The concept of anti-DNA antibodies being instrumental in the pathogenesis of lupus nephritis emerged ~50 years ago, and has been a topic of debate ever since. This article focuses on the description of the renal sub-cellular targets of nephritogenic autoantibodies and offers a counter-point opinion to the article by Pedersen et al. In addition, we provide an overview of some of the mechanisms by which anti-DNA antibodies bind to their renal targets and the pathogenic relevance to clinical nephritis.

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The Role of Anti-DNA Antibodies in the Development of Lupus Nephritis: A Complementary, or Alternative, Viewpoint?

Abstract

Bibliographical note

Keywords

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