Abstract
Kidney disease, or lupus nephritis, is the organ involvement that is most closely associated with specific autoantibodies in patients with SLE. The concept of anti-DNA antibodies being instrumental in the pathogenesis of lupus nephritis emerged ~50 years ago, and has been a topic of debate ever since. This article focuses on the description of the renal sub-cellular targets of nephritogenic autoantibodies and offers a counter-point opinion to the article by Pedersen et al. In addition, we provide an overview of some of the mechanisms by which anti-DNA antibodies bind to their renal targets and the pathogenic relevance to clinical nephritis.
| Original language | English |
|---|---|
| Pages (from-to) | 439-443 |
| Number of pages | 5 |
| Journal | Seminars in Nephrology |
| Volume | 35 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 2015 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2015 Elsevier Inc.
Funding
Financial support: Supported by the National Institutes of Health (R01 AR048692 to C.P.).
| Funders | Funder number |
|---|---|
| National Institutes of Health | R01 AR048692 |
| National Center for Advancing Translational Sciences | UL1TR001073 |
Keywords
- Anti-DNA antibodies
- Cross-reactivity
- Lupus nephritis
- Nephritogenic antibodies