TY - JOUR
T1 - The relationship of premorbid functioning to illness course in schizophrenia and psychotic mood disorders during two years following first hospitalization
AU - Haim, Rachel
AU - Rabinowitz, Jonathan
AU - Bromet, Evelyn
PY - 2006/10
Y1 - 2006/10
N2 - Studies suggest that better premorbid functioning is associated with better outcomes in chronic schizophrenia. Yet first admission studies, which are more appropriate to examine this, are less conclusive. Also, little attention has been given to whether these findings hold for other psychoses. We examined the relationship of premorbid functioning using the Premorbid Adjustment Scale and outcomes in first admission psychoses (schizophrenia, N = 177; bipolar disorder, N = 106; major depression, N = 68) in the Suffolk County-wide mental health project. Poor premorbid functioning was associated with worse outcomes in all three diagnostic groups. Specifically, it was associated with more negative symptoms early in the course of illness, less improvement in negative symptoms, poorer overall clinical functioning, and poorer social functioning. Consistent with new epidemiological research, early assessment of premorbid functioning could provide an avenue for targeted interventions that might improve outcomes.
AB - Studies suggest that better premorbid functioning is associated with better outcomes in chronic schizophrenia. Yet first admission studies, which are more appropriate to examine this, are less conclusive. Also, little attention has been given to whether these findings hold for other psychoses. We examined the relationship of premorbid functioning using the Premorbid Adjustment Scale and outcomes in first admission psychoses (schizophrenia, N = 177; bipolar disorder, N = 106; major depression, N = 68) in the Suffolk County-wide mental health project. Poor premorbid functioning was associated with worse outcomes in all three diagnostic groups. Specifically, it was associated with more negative symptoms early in the course of illness, less improvement in negative symptoms, poorer overall clinical functioning, and poorer social functioning. Consistent with new epidemiological research, early assessment of premorbid functioning could provide an avenue for targeted interventions that might improve outcomes.
KW - Course
KW - Premorbid functioning
KW - Schizophrenia and affective psychosis
UR - http://www.scopus.com/inward/record.url?scp=33750069733&partnerID=8YFLogxK
U2 - 10.1097/01.nmd.0000240158.39929.e3
DO - 10.1097/01.nmd.0000240158.39929.e3
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C2 - 17041293
AN - SCOPUS:33750069733
SN - 0022-3018
VL - 194
SP - 791
EP - 795
JO - Journal of Nervous and Mental Disease
JF - Journal of Nervous and Mental Disease
IS - 10
ER -