Abstract
Nek6 and Nek7 are evolutionarily conserved murine kinases structurally related to the Aspergillus mitotic-regulator NIMA (Genomics 68 (2000) 187). Comparative in situ examination of their patterns of expression revealed that during early embryogenesis nek6 is highly expressed in primary giant trophoblast cells, while nek7 is expressed in the site of decidual reaction. Later in embryogenesis, both RNAs are almost exclusively restricted to the nervous system. nek6 is found in ventricular and sub-ventricular regions, while nek7 is highly expressed in the dorsal thalamus. In the adult brain, distinct nuclei express the two genes. The lineage- and tissue-specific patterns of expression suggest that the two NIMA-related kinases have (additional) functions that are not related to the mitotic functions of NIMA.
| Original language | English |
|---|---|
| Pages (from-to) | 219-223 |
| Number of pages | 5 |
| Journal | Mechanisms of Development |
| Volume | 110 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Jan 2002 |
Bibliographical note
Funding Information:This work was supported by the Israel Cancer Research Fund. We thank Jay Cross for providing the PL-1 cDNA and Gal Yadid for critical reading of the manuscript.
Funding
This work was supported by the Israel Cancer Research Fund. We thank Jay Cross for providing the PL-1 cDNA and Gal Yadid for critical reading of the manuscript.
| Funders | Funder number |
|---|---|
| Israel Cancer Research Fund |
Keywords
- Decidua
- Expression
- Giant trophoblast
- Mouse development
- NIMA
- Nervous system
- Protein kinase