The reaction mechanism of nitrosothiols with copper(I)

Ariela Burg; Haim Cohen; Dan Meyerstein

doi:10.1007/s007750050365

The reaction mechanism of nitrosothiols with copper(I)

Ariela Burg, Haim Cohen, Dan Meyerstein

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Copper and other transition metal ions and their complexes are catalysts for the decomposition of nitrosothiols. In this way they catalyze the biological functions of nitrosothiols. The kinetics and mechanism of the reaction of two nitrosothiols, S-nitrosothiolactic acid and S- nitrosoglutathione (GSNO), with copper(I) are reported. The kinetics of the reaction of Cu(MeCN)(n)/⁺ (n=0-3) with the nitrosothiols were studied. The results indicate that Cu(aq)/⁺ is the active species in the GSNO system, with k(Cu(aq)/⁺+GSNO)=(9.4±2.0) x 10⁷ dm³ mol^-1 s^-1. The results also indicate that the Cu(MeCN)(n)/⁺ (n=0-3) complexes react with S- nitrosothiolactic acid. Transient species are formed in these processes. The results suggest that these species contain copper(I) and thiol. The results shed light on the catalytic role of copper complexes in the decomposition of S-nitrosothiols.

Original language	English
Pages (from-to)	213-217
Number of pages	5
Journal	Journal of Biological Inorganic Chemistry
Volume	5
Issue number	2
DOIs	https://doi.org/10.1007/s007750050365
State	Published - Apr 2000
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgements This study was supported in part by the Israel Science Foundation administered by The Israel Academy of Sciences and Humanities and by a grant from the Budgeting and Planning Committee of The Council of Higher Education. D.M. wishes to express his thanks to Mrs. Irene Evens for her ongoing interest and support.

Funding

Acknowledgements This study was supported in part by the Israel Science Foundation administered by The Israel Academy of Sciences and Humanities and by a grant from the Budgeting and Planning Committee of The Council of Higher Education. D.M. wishes to express his thanks to Mrs. Irene Evens for her ongoing interest and support.

Funders	Funder number
Israel Academy of Sciences and Humanities
Israel Science Foundation
Planning and Budgeting Committee of the Council for Higher Education of Israel

Keywords

Catalysis
Copper(I)
Nitric oxide
Nitrosothiols

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10.1007/s007750050365

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title = "The reaction mechanism of nitrosothiols with copper(I)",

abstract = "Copper and other transition metal ions and their complexes are catalysts for the decomposition of nitrosothiols. In this way they catalyze the biological functions of nitrosothiols. The kinetics and mechanism of the reaction of two nitrosothiols, S-nitrosothiolactic acid and S- nitrosoglutathione (GSNO), with copper(I) are reported. The kinetics of the reaction of Cu(MeCN)(n)/+ (n=0-3) with the nitrosothiols were studied. The results indicate that Cu(aq)/+ is the active species in the GSNO system, with k(Cu(aq)/++GSNO)=(9.4±2.0) x 107 dm3 mol-1 s-1. The results also indicate that the Cu(MeCN)(n)/+ (n=0-3) complexes react with S- nitrosothiolactic acid. Transient species are formed in these processes. The results suggest that these species contain copper(I) and thiol. The results shed light on the catalytic role of copper complexes in the decomposition of S-nitrosothiols.",

keywords = "Catalysis, Copper(I), Nitric oxide, Nitrosothiols",

author = "Ariela Burg and Haim Cohen and Dan Meyerstein",

note = "Funding Information: Acknowledgements This study was supported in part by the Israel Science Foundation administered by The Israel Academy of Sciences and Humanities and by a grant from the Budgeting and Planning Committee of The Council of Higher Education. D.M. wishes to express his thanks to Mrs. Irene Evens for her ongoing interest and support.",

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AU - Cohen, Haim

AU - Meyerstein, Dan

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PY - 2000/4

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N2 - Copper and other transition metal ions and their complexes are catalysts for the decomposition of nitrosothiols. In this way they catalyze the biological functions of nitrosothiols. The kinetics and mechanism of the reaction of two nitrosothiols, S-nitrosothiolactic acid and S- nitrosoglutathione (GSNO), with copper(I) are reported. The kinetics of the reaction of Cu(MeCN)(n)/+ (n=0-3) with the nitrosothiols were studied. The results indicate that Cu(aq)/+ is the active species in the GSNO system, with k(Cu(aq)/++GSNO)=(9.4±2.0) x 107 dm3 mol-1 s-1. The results also indicate that the Cu(MeCN)(n)/+ (n=0-3) complexes react with S- nitrosothiolactic acid. Transient species are formed in these processes. The results suggest that these species contain copper(I) and thiol. The results shed light on the catalytic role of copper complexes in the decomposition of S-nitrosothiols.

AB - Copper and other transition metal ions and their complexes are catalysts for the decomposition of nitrosothiols. In this way they catalyze the biological functions of nitrosothiols. The kinetics and mechanism of the reaction of two nitrosothiols, S-nitrosothiolactic acid and S- nitrosoglutathione (GSNO), with copper(I) are reported. The kinetics of the reaction of Cu(MeCN)(n)/+ (n=0-3) with the nitrosothiols were studied. The results indicate that Cu(aq)/+ is the active species in the GSNO system, with k(Cu(aq)/++GSNO)=(9.4±2.0) x 107 dm3 mol-1 s-1. The results also indicate that the Cu(MeCN)(n)/+ (n=0-3) complexes react with S- nitrosothiolactic acid. Transient species are formed in these processes. The results suggest that these species contain copper(I) and thiol. The results shed light on the catalytic role of copper complexes in the decomposition of S-nitrosothiols.

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The reaction mechanism of nitrosothiols with copper(I)

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