The reaction mechanism of nitrosothiols with copper(I)

Ariela Burg, Haim Cohen, Dan Meyerstein

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28 Scopus citations


Copper and other transition metal ions and their complexes are catalysts for the decomposition of nitrosothiols. In this way they catalyze the biological functions of nitrosothiols. The kinetics and mechanism of the reaction of two nitrosothiols, S-nitrosothiolactic acid and S- nitrosoglutathione (GSNO), with copper(I) are reported. The kinetics of the reaction of Cu(MeCN)(n)/+ (n=0-3) with the nitrosothiols were studied. The results indicate that Cu(aq)/+ is the active species in the GSNO system, with k(Cu(aq)/++GSNO)=(9.4±2.0) x 107 dm3 mol-1 s-1. The results also indicate that the Cu(MeCN)(n)/+ (n=0-3) complexes react with S- nitrosothiolactic acid. Transient species are formed in these processes. The results suggest that these species contain copper(I) and thiol. The results shed light on the catalytic role of copper complexes in the decomposition of S-nitrosothiols.

Original languageEnglish
Pages (from-to)213-217
Number of pages5
JournalJournal of Biological Inorganic Chemistry
Issue number2
StatePublished - Apr 2000
Externally publishedYes

Bibliographical note

Funding Information:
Acknowledgements This study was supported in part by the Israel Science Foundation administered by The Israel Academy of Sciences and Humanities and by a grant from the Budgeting and Planning Committee of The Council of Higher Education. D.M. wishes to express his thanks to Mrs. Irene Evens for her ongoing interest and support.


  • Catalysis
  • Copper(I)
  • Nitric oxide
  • Nitrosothiols


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