The prognostic significance of glial fibrillary acidic protein staining in medulloblastoma

Hadassa Goldberg‐Stern, Natan Gadoth, Sidi Stern, Uri Sandbank, Ian J. Cohen, Rina Zaizov

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Histologic and immunohistochemical properties of 53 medulloblastomas were analyzed with regard to clinical features and survival rate. No correlation was found between survival rate and histologic features of the tumor, such as desmoplastic reaction, number of mitoses, hemorrhages, necrosis, endothelial proliferation, glomerular arrangement, calcifications, rosettes, or oligodendroglial cells. However 82% of the patients with positive glial fibrillary acidic protein (GFAP) staining in numerous tumor cells survived more than 5 years; only 30% survived that long if their tumor cells were GFAP negative (P = 0.0093). This significant difference was not related to the mode of therapeutic protocol used. The authors suggest that GFAP staining may be a useful prognostic tool in medulloblastoma.

Original languageEnglish
Pages (from-to)568-573
Number of pages6
Issue number3
StatePublished - 1 Aug 1991
Externally publishedYes


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