The origin of B cell recurrent chromosomal translocations: Proximity versus DNA damage

Rafael Casellas; Wolfgang Resch; Ofir Hakim; Michel C. Nussenzweig

doi:10.1016/j.molcel.2013.07.020

The origin of B cell recurrent chromosomal translocations: Proximity versus DNA damage

Rafael Casellas
, Wolfgang Resch
, Ofir Hakim
, Michel C. Nussenzweig

National Institutes of Health
Laboratory of Cancer Biology and Genetics
Laboratory of Molecular Immunology
Rockefeller University

Research output: Contribution to journal › Letter › peer-review

5 Scopus citations

Abstract

B cell lymphomas are characterized by recurrent chromosomal translocations. Why these events are so prevalent is an area of active investigation. Several ideas have been put forward to try to explain this phenomenon, including: nuclear proximity between translocating genes; repeated DNA damage by enzymes that mediate Ig gene recombination (AID and RAGs); and selection for deregulated oncogenes.

Original language	English
Pages (from-to)	275-276
Number of pages	2
Journal	Molecular Cell
Volume	51
Issue number	3
DOIs	https://doi.org/10.1016/j.molcel.2013.07.020
State	Published - 8 Aug 2013
Externally published	Yes

Funding

Funders	Funder number
National Institute of Arthritis and Musculoskeletal and Skin Diseases	ZIAAR041148

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10.1016/j.molcel.2013.07.020

Cite this

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abstract = "B cell lymphomas are characterized by recurrent chromosomal translocations. Why these events are so prevalent is an area of active investigation. Several ideas have been put forward to try to explain this phenomenon, including: nuclear proximity between translocating genes; repeated DNA damage by enzymes that mediate Ig gene recombination (AID and RAGs); and selection for deregulated oncogenes. ",

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AB - B cell lymphomas are characterized by recurrent chromosomal translocations. Why these events are so prevalent is an area of active investigation. Several ideas have been put forward to try to explain this phenomenon, including: nuclear proximity between translocating genes; repeated DNA damage by enzymes that mediate Ig gene recombination (AID and RAGs); and selection for deregulated oncogenes.

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The origin of B cell recurrent chromosomal translocations: Proximity versus DNA damage

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