The orcadian cycle effects of dsip on colonic temperature, blood pressure, and heart rate in control and area postrema-lesioned rats

Shlomo Yehuda, Tamir Caspy, Ralph L. Carasso

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Groups of control and Area Postrema rats were treated with 0.1 mg/kg, i.p., DSIP or with saline, at 06:00, 09:00, 12:00, 15:00, 18:00, 2 1:00, 24:00. and at 03:00. Colonic temperature, blood pressure, and heart rate were measured 30min after treatment. DSIP induced a shift in the hyperthermic cycle of control rats, but was unable to modify the noncyclic hypothermia found among Area Postrema-lesioned rats. Furthermore, DSIP caused a decrease in the blood pressure level of control rats, but had no such effect on the already depressed level of blood pressure in the Area Postrema-lesioned rats. Finally, DSIP decreased the heart rate of control rats and significantly antagonized the elevated heart rate observed in the Area Postrema-lesioned rats. The data do not permit us directly to relate the physiological change induced by DSIP to its sleep-promoting effects.

Original languageEnglish
Pages (from-to)259-265
Number of pages7
JournalInternational Journal of Neuroscience
Volume42
Issue number3-4
DOIs
StatePublished - Oct 1988

Bibliographical note

Funding Information:
This study wa:j partly supported by the Research Authority of Bar-Ilan University, Ramat-Gan, Israel. Thanks are due to Elisabeth Sherwin for her help in all phases of preparation of this paper, and to Shlomit Bercovitch and Shad Cohen for their technical assistance.

Funding

This study wa:j partly supported by the Research Authority of Bar-Ilan University, Ramat-Gan, Israel. Thanks are due to Elisabeth Sherwin for her help in all phases of preparation of this paper, and to Shlomit Bercovitch and Shad Cohen for their technical assistance.

FundersFunder number
Research Authority of Bar-Ilan University

    Keywords

    • Area postrema
    • Blood pressure
    • Colonic temperature
    • DSIP
    • Heart rate

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