The orcadian cycle effects of dsip on colonic temperature, blood pressure, and heart rate in control and area postrema-lesioned rats

Shlomo Yehuda, Tamir Caspy, Ralph L. Carasso

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Groups of control and Area Postrema rats were treated with 0.1 mg/kg, i.p., DSIP or with saline, at 06:00, 09:00, 12:00, 15:00, 18:00, 2 1:00, 24:00. and at 03:00. Colonic temperature, blood pressure, and heart rate were measured 30min after treatment. DSIP induced a shift in the hyperthermic cycle of control rats, but was unable to modify the noncyclic hypothermia found among Area Postrema-lesioned rats. Furthermore, DSIP caused a decrease in the blood pressure level of control rats, but had no such effect on the already depressed level of blood pressure in the Area Postrema-lesioned rats. Finally, DSIP decreased the heart rate of control rats and significantly antagonized the elevated heart rate observed in the Area Postrema-lesioned rats. The data do not permit us directly to relate the physiological change induced by DSIP to its sleep-promoting effects.

Original languageEnglish
Pages (from-to)259-265
Number of pages7
JournalInternational Journal of Neuroscience
Volume42
Issue number3-4
DOIs
StatePublished - 1988

Bibliographical note

Funding Information:
This study wa:j partly supported by the Research Authority of Bar-Ilan University, Ramat-Gan, Israel. Thanks are due to Elisabeth Sherwin for her help in all phases of preparation of this paper, and to Shlomit Bercovitch and Shad Cohen for their technical assistance.

Keywords

  • Area postrema
  • Blood pressure
  • Colonic temperature
  • DSIP
  • Heart rate

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