Abstract
Groups of control and Area Postrema rats were treated with 0.1 mg/kg, i.p., DSIP or with saline, at 06:00, 09:00, 12:00, 15:00, 18:00, 2 1:00, 24:00. and at 03:00. Colonic temperature, blood pressure, and heart rate were measured 30min after treatment. DSIP induced a shift in the hyperthermic cycle of control rats, but was unable to modify the noncyclic hypothermia found among Area Postrema-lesioned rats. Furthermore, DSIP caused a decrease in the blood pressure level of control rats, but had no such effect on the already depressed level of blood pressure in the Area Postrema-lesioned rats. Finally, DSIP decreased the heart rate of control rats and significantly antagonized the elevated heart rate observed in the Area Postrema-lesioned rats. The data do not permit us directly to relate the physiological change induced by DSIP to its sleep-promoting effects.
| Original language | English |
|---|---|
| Pages (from-to) | 259-265 |
| Number of pages | 7 |
| Journal | International Journal of Neuroscience |
| Volume | 42 |
| Issue number | 3-4 |
| DOIs | |
| State | Published - Oct 1988 |
Bibliographical note
Funding Information:This study wa:j partly supported by the Research Authority of Bar-Ilan University, Ramat-Gan, Israel. Thanks are due to Elisabeth Sherwin for her help in all phases of preparation of this paper, and to Shlomit Bercovitch and Shad Cohen for their technical assistance.
Funding
This study wa:j partly supported by the Research Authority of Bar-Ilan University, Ramat-Gan, Israel. Thanks are due to Elisabeth Sherwin for her help in all phases of preparation of this paper, and to Shlomit Bercovitch and Shad Cohen for their technical assistance.
| Funders | Funder number |
|---|---|
| Research Authority of Bar-Ilan University |
Keywords
- Area postrema
- Blood pressure
- Colonic temperature
- DSIP
- Heart rate