Abstract
Groups of control and Area Postrema rats were treated with 0.1 mg/kg, i.p., DSIP or with saline, at 06:00, 09:00, 12:00, 15:00, 18:00, 2 1:00, 24:00. and at 03:00. Colonic temperature, blood pressure, and heart rate were measured 30min after treatment. DSIP induced a shift in the hyperthermic cycle of control rats, but was unable to modify the noncyclic hypothermia found among Area Postrema-lesioned rats. Furthermore, DSIP caused a decrease in the blood pressure level of control rats, but had no such effect on the already depressed level of blood pressure in the Area Postrema-lesioned rats. Finally, DSIP decreased the heart rate of control rats and significantly antagonized the elevated heart rate observed in the Area Postrema-lesioned rats. The data do not permit us directly to relate the physiological change induced by DSIP to its sleep-promoting effects.
| Original language | English |
|---|---|
| Pages (from-to) | 259-265 |
| Number of pages | 7 |
| Journal | International Journal of Neuroscience |
| Volume | 42 |
| Issue number | 3-4 |
| DOIs | |
| State | Published - 1988 |
Bibliographical note
Funding Information:This study wa:j partly supported by the Research Authority of Bar-Ilan University, Ramat-Gan, Israel. Thanks are due to Elisabeth Sherwin for her help in all phases of preparation of this paper, and to Shlomit Bercovitch and Shad Cohen for their technical assistance.
Keywords
- Area postrema
- Blood pressure
- Colonic temperature
- DSIP
- Heart rate