The ontogeny of the postingestive inhibitory effect of peptone in rats

Aron Weller, Ludmila Tsitolovskya

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Abstract

The ontogeny of the postingestive inhibitory control of intake by protein digestion products was investigated by administering gastric preloads of a peptone that was a hydrolysate of meat and that decreased intake in adult rats [Am. J. Physiol., Regul. Integr. Comp. Physiol. 276 (1999) R1623; Am. J. Physiol., Regul. Integr. Comp. Physiol. 277 (1999) R1144]. Gastric preloads of saline or peptone, or sham preloads were given 5 min before a 30-min, independent ingestion test in which pups had access to a sweet, high-fat milk diet. Preloads of isotonic peptone reduced intake significantly more than preloads of isotonic saline on postnatal day (P) 18, but not on P12. Pretreatment with the CCKA receptor antagonist devazepide (600 μg/kg ip) did not change the inhibitory effect of isotonic peptone. Thus, the inhibitory effect of peptone on P18 was apparently not mediated by endogenous CCK acting at CCKA receptors. In contrast to isotonic peptone, preloads of hypertonic peptone did not decrease intake more than preloads of hypertonic saline on P12, P18, or P24. We conclude that if the isotonic peptone used in these experiments is an adequate model of the digestion products of dietary protein at these postnatal ages, then the postingestive inhibitory control of intake by digestion products of dietary protein during independent ingestion appears between P13 and P18.

Original languageEnglish
Pages (from-to)11-16
Number of pages6
JournalPhysiology and Behavior
Volume82
Issue number1
DOIs
StatePublished - Aug 2004

Funding

The authors thank Ofra Schwartz for technical assistance. This research was supported by a grant from the US–Israel Binational Science Foundation (BSF). AW is partially supported by the Paula Rich center, Bar Ilan University. The authors thank Dr. T.H. Moran for fruitful discussions of portions of these data. Dr. G.P. Smith was a co-PI on the BSF grant and a collaborator on the current project. The authors thank him for his contribution to the research and to the manuscript.

FundersFunder number
Bar Ilan University
US-Israel Binational Science Foundation
Bloom's Syndrome Foundation

    Keywords

    • Hypertonic saline
    • Ontogeny
    • Peptone
    • Postingestive effect

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