Abstract
Lupus nephritis, a potentially devastating outcome of systemic lupus erythematosus (SLE), poses a real challenge in the management of SLE patients because of the difficulty in diagnosing its onset and identifying relapses before serious renal damage has ensued. Neutrophil gelatinase-B associated lipocalin (NGAL)/Lipocalin-2 has been implicated in the pathogenesis of several disease states in different organ systems, and especially in kidney diseases. Lipocalin-2 may play a protective role in the context of renal insults through the induction or prevention of apoptosis by an iron-transport dependent mechanism. Clinically, urinary Lipocalin-2 significantly correlates with measures of lupus nephritis disease activity, and may be an important and convenient marker for relapses.
| Original language | English |
|---|---|
| Pages (from-to) | 229-234 |
| Number of pages | 6 |
| Journal | Autoimmunity Reviews |
| Volume | 7 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 2008 |
| Externally published | Yes |
Keywords
- Biomarkers
- Lipocalin-2
- Lupus nephritis
- NGAL
- Neutrophil gelatinase-B associated lipocalin
- Systemic lupus erythematosus
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