The m6A epitranscriptome: transcriptome plasticity in brain development and function

Ido Livneh; Sharon Moshitch-Moshkovitz; Ninette Amariglio; Gideon Rechavi; Dan Dominissini

doi:10.1038/s41583-019-0244-z

The m⁶A epitranscriptome: transcriptome plasticity in brain development and function

Ido Livneh, Sharon Moshitch-Moshkovitz, Ninette Amariglio, Gideon Rechavi, Dan Dominissini

The Mina and Everard Goodman Faculty of Life Sciences

Research output: Contribution to journal › Review article › peer-review

202 Scopus citations

Abstract

The field of epitranscriptomics examines the recently deciphered form of gene expression regulation that is mediated by type- and site-specific RNA modifications. Similarly to the role played by epigenetic mechanisms — which operate via DNA and histone modifications — epitranscriptomic modifications are involved in the control of the delicate gene expression patterns that are needed for the development and activity of the nervous system and are essential for basic and higher brain functions. Here we describe the mechanisms that are involved in the writing, erasing and reading of N⁶-methyladenosine, the most prevalent internal mRNA modification, and the emerging roles played by N⁶-methyladenosine in the nervous system.

Original language	English
Pages (from-to)	36-51
Number of pages	16
Journal	Nature Reviews Neuroscience
Volume	21
Issue number	1
Early online date	5 Dec 2019
DOIs	https://doi.org/10.1038/s41583-019-0244-z
State	Published - 1 Jan 2020

Bibliographical note

Publisher Copyright:
© 2019, Springer Nature Limited.

Funding

The authors thank the Kahn Family Foundation for continuous support of their research. D.D is supported by grants from the Israel Science Foundation (2494/18 and 2625/17) and the Human Frontier Science Program (CDA 00048/2018). G.R. and D.D are supported by the German– Israeli Project Cooperation (DIP) of the German Federal Ministry of Education and Research.

Funders	Funder number
DIP
German– Israeli Project Cooperation
Human Frontier Science Program	CDA 00048/2018
Bundesministerium für Bildung und Forschung
Israel Science Foundation	2494/18, 2625/17

Access to Document

10.1038/s41583-019-0244-z

Cite this

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