Abstract
Avigad Laron et al. show that the mesenchymal niche of the hair follicle, the dermal papilla (DP), regulates bulge stem cell properties during quiescence and regeneration. While the DP initiates regeneration by downregulating bulge-dependent inhibitory effects, it coordinates the progression of regeneration by an autoregulatory circuit that controls Shh expression in adjacent progenitors and Wnt signaling in DP cells.
| Original language | English |
|---|---|
| Pages (from-to) | 909-921.e3 |
| Journal | Cell Reports |
| Volume | 24 |
| Issue number | 4 |
| DOIs | |
| State | Published - 24 Jul 2018 |
Bibliographical note
Funding Information:This research was funded by the USA-Israel Binational Science Foundation (BSF) (2013375) and the Israel Science Foundation (ISF) (1304/14). We thank Eitan Winter for the bioinformatics analysis and Hofesh Haruach for technical support.
Funding Information:
This research was funded by the USA-Israel Binational Science Foundation ( BSF ) ( 2013375 ) and the Israel Science Foundation (ISF) ( 1304/14 ). We thank Eitan Winter for the bioinformatics analysis and Hofesh Haruach for technical support.
Funding
This research was funded by the USA-Israel Binational Science Foundation (BSF) (2013375) and the Israel Science Foundation (ISF) (1304/14). We thank Eitan Winter for the bioinformatics analysis and Hofesh Haruach for technical support. This research was funded by the USA-Israel Binational Science Foundation ( BSF ) ( 2013375 ) and the Israel Science Foundation (ISF) ( 1304/14 ). We thank Eitan Winter for the bioinformatics analysis and Hofesh Haruach for technical support.
| Funders | Funder number |
|---|---|
| USA-Israel Binational Science Foundation | |
| Bloom's Syndrome Foundation | |
| United States-Israel Binational Science Foundation | 2013375 |
| Israel Science Foundation | 1304/14 |
Keywords
- dermal papilla
- hair follicle
- mesenchymal niche
- regeneration
- stem cell quiescence