The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells

Efrat Avigad Laron, Emil Aamar, David Enshell-Seijffers

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Avigad Laron et al. show that the mesenchymal niche of the hair follicle, the dermal papilla (DP), regulates bulge stem cell properties during quiescence and regeneration. While the DP initiates regeneration by downregulating bulge-dependent inhibitory effects, it coordinates the progression of regeneration by an autoregulatory circuit that controls Shh expression in adjacent progenitors and Wnt signaling in DP cells.

Original languageEnglish
Pages (from-to)909-921.e3
JournalCell Reports
Volume24
Issue number4
DOIs
StatePublished - 24 Jul 2018

Bibliographical note

Funding Information:
This research was funded by the USA-Israel Binational Science Foundation (BSF) (2013375) and the Israel Science Foundation (ISF) (1304/14). We thank Eitan Winter for the bioinformatics analysis and Hofesh Haruach for technical support.

Funding Information:
This research was funded by the USA-Israel Binational Science Foundation ( BSF ) ( 2013375 ) and the Israel Science Foundation (ISF) ( 1304/14 ). We thank Eitan Winter for the bioinformatics analysis and Hofesh Haruach for technical support.

Keywords

  • dermal papilla
  • hair follicle
  • mesenchymal niche
  • regeneration
  • stem cell quiescence

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