TY - JOUR
T1 - The Mdm2 oncoprotein interacts with the cell fate regulator numb
AU - Juven-Gershon, Tamar
AU - Shifman, Ohad
AU - Unger, Tamar
AU - Elkeles, Adi
AU - Haupt, Ygal
AU - Oren, Moshe
PY - 1998/7
Y1 - 1998/7
N2 - The Mdm2 oncoprotein is a well-known inhibitor of the p53 tumor suppressor, but it may also possess p53-independent activities. In search of such p53-independent activities, the yeast two-hybrid screen was employed to identify Mdm2-binding proteins. We report that in vitro and in transfected cells, Mdm2 can associate with Numb, a protein involved in the determination of cell fate. This association causes translocation of overexpressed Numb into the nucleus and leads to a reduction in overall cellular Numb levels. Through its interaction with Numb, Mdm2 may influence processes such as differentiation and survival. This could potentially contribute to the altered properties of tumor cells which overexpress Mdm2.
AB - The Mdm2 oncoprotein is a well-known inhibitor of the p53 tumor suppressor, but it may also possess p53-independent activities. In search of such p53-independent activities, the yeast two-hybrid screen was employed to identify Mdm2-binding proteins. We report that in vitro and in transfected cells, Mdm2 can associate with Numb, a protein involved in the determination of cell fate. This association causes translocation of overexpressed Numb into the nucleus and leads to a reduction in overall cellular Numb levels. Through its interaction with Numb, Mdm2 may influence processes such as differentiation and survival. This could potentially contribute to the altered properties of tumor cells which overexpress Mdm2.
UR - http://www.scopus.com/inward/record.url?scp=0031835660&partnerID=8YFLogxK
U2 - 10.1128/MCB.18.7.3974
DO - 10.1128/MCB.18.7.3974
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C2 - 9632782
AN - SCOPUS:0031835660
SN - 0270-7306
VL - 18
SP - 3974
EP - 3982
JO - Molecular and Cellular Biology
JF - Molecular and Cellular Biology
IS - 7
ER -