The MCCB impairment profile for schizophrenia outpatients: Results from the MATRICS psychometric and standardization study

Robert S. Kern; James M. Gold; Dwight Dickinson; Michael F. Green; Keith H. Nuechterlein; Lyle E. Baade; Richard S.E. Keefe; Raquelle I. Mesholam-Gately; Larry J. Seidman; Cathy Lee; Catherine A. Sugar; Stephen R. Marder

doi:10.1016/j.schres.2010.11.008

The MCCB impairment profile for schizophrenia outpatients: Results from the MATRICS psychometric and standardization study

Robert S. Kern, James M. Gold, Dwight Dickinson, Michael F. Green, Keith H. Nuechterlein, Lyle E. Baade, Richard S.E. Keefe, Raquelle I. Mesholam-Gately, Larry J. Seidman, Cathy Lee, Catherine A. Sugar, Stephen R. Marder

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202 Scopus citations

Abstract

The MATRICS Psychometric and Standardization Study was conducted as a final stage in the development of the MATRICS Consensus Cognitive Battery (MCCB). The study included 176 persons with schizophrenia or schizoaffective disorder and 300 community residents. Data were analyzed to examine the cognitive profile of clinically stable schizophrenia patients on the MCCB. Secondarily, the data were analyzed to identify which combination of cognitive domains and corresponding cut-off scores best discriminated patients from community residents, and patients competitively employed vs. those not. Raw scores on the ten MCCB tests were entered into the MCCB scoring program which provided age- and gender-corrected T-scores on seven cognitive domains. To test for between-group differences, we conducted a 2 (group) × 7 (cognitive domain) MANOVA with follow-up independent t-tests on the individual domains. Classification and regression trees (CART) were used for the discrimination analyses. Examination of patient T-scores across the seven cognitive domains revealed a relatively compact profile with T-scores ranging from 33.4 for speed of processing to 39.3 for reasoning and problem-solving. Speed of processing and social cognition best distinguished individuals with schizophrenia from community residents; speed of processing along with visual learning and attention/vigilance optimally distinguished patients competitively employed from those who were not. The cognitive profile findings provide a standard to which future studies can compare results from other schizophrenia samples and related disorders; the classification results point to specific areas and levels of cognitive impairment that may advance work rehabilitation efforts.

Original language	English
Pages (from-to)	124-131
Number of pages	8
Journal	Schizophrenia Research
Volume	126
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2010.11.008
State	Published - Mar 2011
Externally published	Yes

Bibliographical note

Funding Information:
Funding for the MATRICS Initiative was provided through Contract N01MH22006 from the National Institute for Mental Health to the University of California, Los Angeles (Dr. Marder, PI; Dr. Green, Co-PI; Dr. Fenton, Project Officer). Funding for this study came from an Option (Dr. Green, PI; Dr. Nuechterlein, Co-PI) to the NIMH MATRICS Initiative. The NIMH had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.

Funding

Funding for the MATRICS Initiative was provided through Contract N01MH22006 from the National Institute for Mental Health to the University of California, Los Angeles (Dr. Marder, PI; Dr. Green, Co-PI; Dr. Fenton, Project Officer). Funding for this study came from an Option (Dr. Green, PI; Dr. Nuechterlein, Co-PI) to the NIMH MATRICS Initiative. The NIMH had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.

Funders	Funder number
National Institute of Mental Health	N01MH022006

Keywords

Cognition
MCCB
Profile
Schizophrenia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.schres.2010.11.008

Cite this

Kern, R. S., Gold, J. M., Dickinson, D., Green, M. F., Nuechterlein, K. H., Baade, L. E., Keefe, R. S. E., Mesholam-Gately, R. I., Seidman, L. J., Lee, C., Sugar, C. A., & Marder, S. R. (2011). The MCCB impairment profile for schizophrenia outpatients: Results from the MATRICS psychometric and standardization study. Schizophrenia Research, 126(1-3), 124-131. https://doi.org/10.1016/j.schres.2010.11.008

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abstract = "The MATRICS Psychometric and Standardization Study was conducted as a final stage in the development of the MATRICS Consensus Cognitive Battery (MCCB). The study included 176 persons with schizophrenia or schizoaffective disorder and 300 community residents. Data were analyzed to examine the cognitive profile of clinically stable schizophrenia patients on the MCCB. Secondarily, the data were analyzed to identify which combination of cognitive domains and corresponding cut-off scores best discriminated patients from community residents, and patients competitively employed vs. those not. Raw scores on the ten MCCB tests were entered into the MCCB scoring program which provided age- and gender-corrected T-scores on seven cognitive domains. To test for between-group differences, we conducted a 2 (group) × 7 (cognitive domain) MANOVA with follow-up independent t-tests on the individual domains. Classification and regression trees (CART) were used for the discrimination analyses. Examination of patient T-scores across the seven cognitive domains revealed a relatively compact profile with T-scores ranging from 33.4 for speed of processing to 39.3 for reasoning and problem-solving. Speed of processing and social cognition best distinguished individuals with schizophrenia from community residents; speed of processing along with visual learning and attention/vigilance optimally distinguished patients competitively employed from those who were not. The cognitive profile findings provide a standard to which future studies can compare results from other schizophrenia samples and related disorders; the classification results point to specific areas and levels of cognitive impairment that may advance work rehabilitation efforts.",

keywords = "Cognition, MCCB, Profile, Schizophrenia",

author = "Kern, {Robert S.} and Gold, {James M.} and Dwight Dickinson and Green, {Michael F.} and Nuechterlein, {Keith H.} and Baade, {Lyle E.} and Keefe, {Richard S.E.} and Mesholam-Gately, {Raquelle I.} and Seidman, {Larry J.} and Cathy Lee and Sugar, {Catherine A.} and Marder, {Stephen R.}",

note = "Funding Information: Funding for the MATRICS Initiative was provided through Contract N01MH22006 from the National Institute for Mental Health to the University of California, Los Angeles (Dr. Marder, PI; Dr. Green, Co-PI; Dr. Fenton, Project Officer). Funding for this study came from an Option (Dr. Green, PI; Dr. Nuechterlein, Co-PI) to the NIMH MATRICS Initiative. The NIMH had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. ",

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Kern, RS, Gold, JM, Dickinson, D, Green, MF, Nuechterlein, KH, Baade, LE, Keefe, RSE, Mesholam-Gately, RI, Seidman, LJ, Lee, C, Sugar, CA & Marder, SR 2011, 'The MCCB impairment profile for schizophrenia outpatients: Results from the MATRICS psychometric and standardization study', Schizophrenia Research, vol. 126, no. 1-3, pp. 124-131. https://doi.org/10.1016/j.schres.2010.11.008

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AU - Sugar, Catherine A.

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AB - The MATRICS Psychometric and Standardization Study was conducted as a final stage in the development of the MATRICS Consensus Cognitive Battery (MCCB). The study included 176 persons with schizophrenia or schizoaffective disorder and 300 community residents. Data were analyzed to examine the cognitive profile of clinically stable schizophrenia patients on the MCCB. Secondarily, the data were analyzed to identify which combination of cognitive domains and corresponding cut-off scores best discriminated patients from community residents, and patients competitively employed vs. those not. Raw scores on the ten MCCB tests were entered into the MCCB scoring program which provided age- and gender-corrected T-scores on seven cognitive domains. To test for between-group differences, we conducted a 2 (group) × 7 (cognitive domain) MANOVA with follow-up independent t-tests on the individual domains. Classification and regression trees (CART) were used for the discrimination analyses. Examination of patient T-scores across the seven cognitive domains revealed a relatively compact profile with T-scores ranging from 33.4 for speed of processing to 39.3 for reasoning and problem-solving. Speed of processing and social cognition best distinguished individuals with schizophrenia from community residents; speed of processing along with visual learning and attention/vigilance optimally distinguished patients competitively employed from those who were not. The cognitive profile findings provide a standard to which future studies can compare results from other schizophrenia samples and related disorders; the classification results point to specific areas and levels of cognitive impairment that may advance work rehabilitation efforts.

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The MCCB impairment profile for schizophrenia outpatients: Results from the MATRICS psychometric and standardization study

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

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