The mammalian Nek1 kinase is involved in primary cilium formation

Ohad Shalom; Nechama Shalva; Yoram Altschuler; Benny Motro

doi:10.1016/j.febslet.2008.03.036

The mammalian Nek1 kinase is involved in primary cilium formation

Ohad Shalom
, Nechama Shalva
, Yoram Altschuler
, Benny Motro

Interdisciplinary Brain Science Program

Bar-Ilan University
Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Abstract

Recent studies implicate primary cilium (PC) proteins in the etiologies of various polycystic kidney diseases (PKD). NIMA-related kinases (NRKs) are conserved serine/threonine kinases, which are usually defined as 'mitotic kinases'. Murine mutants for the NRKs, nek1 (kat mice) suffer from PKD, suggesting that it may be involved in cilium control. We demonstrated herein that Nek1 is localized to basal body region and that Nek1 overexpression inhibits ciliogenesis in Madin-Darby canine kidney epithelial cells. The number of primary cilia is dramatically reduced in kat2J mouse embryonic fibroblasts culture. It is thus hypothesized that Nek1 links cell cycle progression and the PC cycle.

Original language	English
Pages (from-to)	1465-1470
Number of pages	6
Journal	FEBS Letters
Volume	582
Issue number	10
DOIs	https://doi.org/10.1016/j.febslet.2008.03.036
State	Published - 30 Apr 2008

Keywords

Ciliogenesis
Kinase
NIMA
Polycystic kidney disease
Primary cilium

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10.1016/j.febslet.2008.03.036

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title = "The mammalian Nek1 kinase is involved in primary cilium formation",

abstract = "Recent studies implicate primary cilium (PC) proteins in the etiologies of various polycystic kidney diseases (PKD). NIMA-related kinases (NRKs) are conserved serine/threonine kinases, which are usually defined as 'mitotic kinases'. Murine mutants for the NRKs, nek1 (kat mice) suffer from PKD, suggesting that it may be involved in cilium control. We demonstrated herein that Nek1 is localized to basal body region and that Nek1 overexpression inhibits ciliogenesis in Madin-Darby canine kidney epithelial cells. The number of primary cilia is dramatically reduced in kat2J mouse embryonic fibroblasts culture. It is thus hypothesized that Nek1 links cell cycle progression and the PC cycle.",

keywords = "Ciliogenesis, Kinase, NIMA, Polycystic kidney disease, Primary cilium",

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T1 - The mammalian Nek1 kinase is involved in primary cilium formation

AU - Shalom, Ohad

AU - Shalva, Nechama

AU - Altschuler, Yoram

AU - Motro, Benny

PY - 2008/4/30

Y1 - 2008/4/30

N2 - Recent studies implicate primary cilium (PC) proteins in the etiologies of various polycystic kidney diseases (PKD). NIMA-related kinases (NRKs) are conserved serine/threonine kinases, which are usually defined as 'mitotic kinases'. Murine mutants for the NRKs, nek1 (kat mice) suffer from PKD, suggesting that it may be involved in cilium control. We demonstrated herein that Nek1 is localized to basal body region and that Nek1 overexpression inhibits ciliogenesis in Madin-Darby canine kidney epithelial cells. The number of primary cilia is dramatically reduced in kat2J mouse embryonic fibroblasts culture. It is thus hypothesized that Nek1 links cell cycle progression and the PC cycle.

AB - Recent studies implicate primary cilium (PC) proteins in the etiologies of various polycystic kidney diseases (PKD). NIMA-related kinases (NRKs) are conserved serine/threonine kinases, which are usually defined as 'mitotic kinases'. Murine mutants for the NRKs, nek1 (kat mice) suffer from PKD, suggesting that it may be involved in cilium control. We demonstrated herein that Nek1 is localized to basal body region and that Nek1 overexpression inhibits ciliogenesis in Madin-Darby canine kidney epithelial cells. The number of primary cilia is dramatically reduced in kat2J mouse embryonic fibroblasts culture. It is thus hypothesized that Nek1 links cell cycle progression and the PC cycle.

KW - Ciliogenesis

KW - Kinase

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KW - Polycystic kidney disease

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The mammalian Nek1 kinase is involved in primary cilium formation

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