The major histocompatibility complex and inflammation

Arnon Blum, Hylton Miller

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


The major histocompatibility complex (MHC) is of major medical interest because of its contribution to transplant rejection and to variation among individuals in susceptibility to a variety of autoimmune disorders. In addition to its role in influencing the propensity for known autoimmune diseases, the MHC contains genes contributing to several other hereditary disorders that are not autoimmune in nature or in which the role of autoimmunity is uncertain. Recently, a duster of genes encoding inflammation- related proteins were found, and our review focuses on these findings and their clinical relevance.

Original languageEnglish
Pages (from-to)169-172
Number of pages4
JournalSouthern Medical Journal
Issue number2
StatePublished - Feb 2000
Externally publishedYes


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