The lymphoproliferative disease virus of turkeys (LPDV) is the etiological agent of a rapidly developing lymphoproliferative process in turkeys. To better understand the genetic relationships of LPDV to other retroviruses we determined the nucleotide sequence of its pol gene. Comparative computer analyses of the deduced amino acid sequences of the reverse transcriptase and integrase domains within pol established that LPDV represents a distinct class of avian retroviruses that is most closely related to the avian leukemia-sarcoma viruses.
Bibliographical noteFunding Information:
We thank Dr. S.A. Aaronson for his continued support and encouragement.T his study was supported in part by a project grant from the Fund for Basic Research administered by the Israel Academy of Sciences and Humanities, the Israel Cancer Research Fund and the Israel Cancer Association.
- Recombinant DNA
- genetic relatedness
- reverse transcriptase