Ligand-Substitution Reactions of the Tellurium Compound AS-101 in Physiological Aqueous and Alcoholic Solutions

Alon Silberman, Michael Albeck, Benjamin Sredni, Amnon Albeck

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8 Scopus citations

Abstract

Since its first crystallization, the aqueous structure of the tellurium-containing experimental drug AS-101 has never been studied. We show that, under the aqueous conditions in which it is administered, AS-101 is subjected to an immediate ligand-substitution reaction with water, yielding a stable hydrolyzed oxide anion product that is identified, for the first time, to be TeOCl3-. Studying the structure of AS-101 in propylene glycol (PG), an alcoholic solvent often used for the topical and oral administration of AS-101, revealed the same phenomenon of ligand-substitution reaction between the alcoholic ligands. Upon exposure to water, the PG-substituted product is also hydrolyzed to the same tellurium(IV) oxide form, TeOCl3-.

Original languageEnglish
Pages (from-to)10847-10850
Number of pages4
JournalInorganic Chemistry
Volume55
Issue number21
DOIs
StatePublished - 7 Nov 2016

Bibliographical note

Publisher Copyright:
© 2016 American Chemical Society.

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