Abstract
Depressed patients with resistance to electroconvulsive treatment (ECT) had high basal serum levels of dehydroepiandrosterone (DHEA) sulfate (DHEAS). To clarify the role of DHEA/S in the ECT resistance, Flinder Sensitive Line (FSL) rats, which are a genetic animal model of depression, were injected i.p. with 2 mg/kg DHEA daily for 13 days to overload their serum and brain DHEA/S levels. Thereafter, rats were exposed to electroconvulsive shock (ECS), which is analogue to ECT in humans. Both ECS and DHEA displayed an antidepressive-like effect, as assessed by immobility time in forced swim test. However, combined DHEA and ECS treatment abolished these antidepressive-like effects. In addition, the levels of neurosteroids, corticosterone and adrenocorticotropin in selected brain regions were evaluated and compared to serum levels. The present study supports our assumption that high basal levels of DHEA/S play a role in the resistance to ECS and maybe ECT in humans.
| Original language | English |
|---|---|
| Pages (from-to) | 253-262 |
| Number of pages | 10 |
| Journal | European Neuropsychopharmacology |
| Volume | 15 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 2005 |
Bibliographical note
Funding Information:This study was supported partially by a grant from the Sara and Moshe Mayer Foundation for Research to AW, and partially by a grant from The Israel Ministry of Health to GY.
Funding
This study was supported partially by a grant from the Sara and Moshe Mayer Foundation for Research to AW, and partially by a grant from The Israel Ministry of Health to GY.
| Funders | Funder number |
|---|---|
| Sara and Moshe Mayer Foundation for Research | |
| Ministry of Health, State of Israel |
Keywords
- Corticosterone
- Dehydroepiandrosterone (DHEA)
- Depression
- Electroconvulsive shock (ECS)
- Electroconvulsive therapy (ECT)
- Neurosteroids
