The intersection of undernutrition, microbiome, and child development in the first years of life

Fanette Fontaine, Sondra Turjeman, Karel Callens, Omry Koren

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Undernutrition affects about one out of five children worldwide. It is associated with impaired growth, neurodevelopment deficits, and increased infectious morbidity and mortality. Undernutrition, however, cannot be solely attributed to a lack of food or nutrient deficiency but rather results from a complex mix of biological and environmental factors. Recent research has shown that the gut microbiome is intimately involved in the metabolism of dietary components, in growth, in the training of the immune system, and in healthy development. In this review, we look at these features in the first three years of life, which is a critical window for both microbiome establishment and maturation and child development. We also discuss the potential of the microbiome in undernutrition interventions, which could increase efficacy and improve child health outcomes.

Original languageEnglish
Article number3554
JournalNature Communications
Volume14
Issue number1
DOIs
StatePublished - 15 Jun 2023

Bibliographical note

Publisher Copyright:
© 2023, The Author(s).

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