TY - JOUR
T1 - The Interplay of Lipid Signaling in Musculoskeletal Cross Talk
T2 - Implications for Health and Disease
AU - Al Saedi, Ahmed
AU - Yacoub, Ahmed S.
AU - Awad, Kamal
AU - Karasik, David
AU - Brotto, Marco
AU - Duque, Gustavo
N1 - Publisher Copyright:
© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2024
Y1 - 2024
N2 - The intricate interplay between the muscle and bone tissues is a fundamental aspect of musculoskeletal physiology. Over the past decades, emerging research has highlighted the pivotal role of lipid signaling in mediating communication between these tissues. This chapter delves into the multifaceted mechanisms through which lipids, particularly phospholipids, sphingolipids, and eicosanoids, participate in orchestrating cellular responses and metabolic pathways in both muscle and bone. Additionally, we examine the clinical implications of disrupted lipid signaling in musculoskeletal disorders, offering insights into potential therapeutic avenues. This chapter aims to shed light on the complex lipid-driven interactions between the muscle and bone tissues, paving the way for a deeper understanding of musculoskeletal health and disease.
AB - The intricate interplay between the muscle and bone tissues is a fundamental aspect of musculoskeletal physiology. Over the past decades, emerging research has highlighted the pivotal role of lipid signaling in mediating communication between these tissues. This chapter delves into the multifaceted mechanisms through which lipids, particularly phospholipids, sphingolipids, and eicosanoids, participate in orchestrating cellular responses and metabolic pathways in both muscle and bone. Additionally, we examine the clinical implications of disrupted lipid signaling in musculoskeletal disorders, offering insights into potential therapeutic avenues. This chapter aims to shed light on the complex lipid-driven interactions between the muscle and bone tissues, paving the way for a deeper understanding of musculoskeletal health and disease.
KW - Cross talk
KW - Fat
KW - Lipid signaling
KW - Lipids
KW - Musculoskeletal cross talk
UR - http://www.scopus.com/inward/record.url?scp=85198237444&partnerID=8YFLogxK
U2 - 10.1007/978-1-0716-3902-3_1
DO - 10.1007/978-1-0716-3902-3_1
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C2 - 38977583
AN - SCOPUS:85198237444
SN - 1064-3745
VL - 2816
SP - 1
EP - 11
JO - Methods in Molecular Biology
JF - Methods in Molecular Biology
ER -