Abstract
Cell survival was investigated after exposing cells in vitro to different temperatures before or after photodynamic therapy with 5-aminolevulinic acid. The photodynamic process was found to be temperature dependent. Cells exposed for 1 h to 41 °C before light exposure or to 7 °C after light exposure showed decreased survival. Furthermore, the photobleaching rate of protoporphyrin IX in the cells was found to increase with increasing temperature during the light exposure. Thus, the photodynamic effect with 5-aminolevulinic acid may be enhanced by heating the tumour area before, and by cooling it immediately after the treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 161-166 |
| Number of pages | 6 |
| Journal | Journal of Photochemistry and Photobiology B: Biology |
| Volume | 84 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1 Aug 2006 |
Bibliographical note
Funding Information:This work was supported by the Research Foundation of the Norwegian Radium Hospital (RF) and by the Norwegian Cancer Society (Kreftforeningen).
Funding
This work was supported by the Research Foundation of the Norwegian Radium Hospital (RF) and by the Norwegian Cancer Society (Kreftforeningen).
| Funders | Funder number |
|---|---|
| Kreftforeningen | |
| Radiumhospitalets Forskningsstifltelse |
Keywords
- 5-Aminolevulinic acid
- Photodynamic therapy
- Protoporphyrin IX