The increased opiate action of β-endorphin in iron-deficient rats: The possible involvement of dopamine

Shlomo Yehuda; Moussa B.H. Youdim

doi:10.1016/0014-2999(84)90399-6

The increased opiate action of β-endorphin in iron-deficient rats: The possible involvement of dopamine

Shlomo Yehuda
, Moussa B.H. Youdim

Department of Psychology

Technion-Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Rats made nutritionally iron-deficient (ID) have been shown to have a lower brain non-haem. A selective diminution of the binding capacity of the D₂-dopaminergic receptors alone was found among nutritionally iron-deficient rats. Peripherally administered β-endorphin significantly elevated the pain threshold only in the iron-deficient rats. Naloxone blocked the β-endorphin effect in ID rats. Morphine, as well as haloperidol, elevated the pain threshold in both the iron-deficient and the control rats but significantly more in the former group. No additive effects of combined treatment with β-endorphin and haloperidol on pain threshold were found. Other neuroleptics also elevated the pain threshold. A possible hypothesis is that dopamine (via β-endorphin) may play a role in modifying the pain threshold.

Original language	English
Pages (from-to)	245-251
Number of pages	7
Journal	European Journal of Pharmacology
Volume	104
Issue number	3-4
DOIs	https://doi.org/10.1016/0014-2999(84)90399-6
State	Published - 17 Sep 1984

Bibliographical note

Funding Information:
fl-Endorphin was generously donated by the N.I.H., U.S.A. This study was supported in part by research grants from the Bar-llan University Research Authority, by the Sapir Foundation and by the Rappaport Family Institute (Technion).

Funding

fl-Endorphin was generously donated by the N.I.H., U.S.A. This study was supported in part by research grants from the Bar-llan University Research Authority, by the Sapir Foundation and by the Rappaport Family Institute (Technion).

Funders
Bar-llan University Research Authority
Rappaport Family Institute
Sapir Foundation
Technion-Israel Institute of Technology

Keywords

Circadian rhythm
Dopamine
Pain
β-Endorphin

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10.1016/0014-2999(84)90399-6

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title = "The increased opiate action of β-endorphin in iron-deficient rats: The possible involvement of dopamine",

abstract = "Rats made nutritionally iron-deficient (ID) have been shown to have a lower brain non-haem. A selective diminution of the binding capacity of the D2-dopaminergic receptors alone was found among nutritionally iron-deficient rats. Peripherally administered β-endorphin significantly elevated the pain threshold only in the iron-deficient rats. Naloxone blocked the β-endorphin effect in ID rats. Morphine, as well as haloperidol, elevated the pain threshold in both the iron-deficient and the control rats but significantly more in the former group. No additive effects of combined treatment with β-endorphin and haloperidol on pain threshold were found. Other neuroleptics also elevated the pain threshold. A possible hypothesis is that dopamine (via β-endorphin) may play a role in modifying the pain threshold.",

keywords = "Circadian rhythm, Dopamine, Pain, β-Endorphin",

author = "Shlomo Yehuda and Youdim, \{Moussa B.H.\}",

note = "Funding Information: fl-Endorphin was generously donated by the N.I.H., U.S.A. This study was supported in part by research grants from the Bar-llan University Research Authority, by the Sapir Foundation and by the Rappaport Family Institute (Technion).",

year = "1984",

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doi = "10.1016/0014-2999(84)90399-6",

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AU - Youdim, Moussa B.H.

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PY - 1984/9/17

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N2 - Rats made nutritionally iron-deficient (ID) have been shown to have a lower brain non-haem. A selective diminution of the binding capacity of the D2-dopaminergic receptors alone was found among nutritionally iron-deficient rats. Peripherally administered β-endorphin significantly elevated the pain threshold only in the iron-deficient rats. Naloxone blocked the β-endorphin effect in ID rats. Morphine, as well as haloperidol, elevated the pain threshold in both the iron-deficient and the control rats but significantly more in the former group. No additive effects of combined treatment with β-endorphin and haloperidol on pain threshold were found. Other neuroleptics also elevated the pain threshold. A possible hypothesis is that dopamine (via β-endorphin) may play a role in modifying the pain threshold.

AB - Rats made nutritionally iron-deficient (ID) have been shown to have a lower brain non-haem. A selective diminution of the binding capacity of the D2-dopaminergic receptors alone was found among nutritionally iron-deficient rats. Peripherally administered β-endorphin significantly elevated the pain threshold only in the iron-deficient rats. Naloxone blocked the β-endorphin effect in ID rats. Morphine, as well as haloperidol, elevated the pain threshold in both the iron-deficient and the control rats but significantly more in the former group. No additive effects of combined treatment with β-endorphin and haloperidol on pain threshold were found. Other neuroleptics also elevated the pain threshold. A possible hypothesis is that dopamine (via β-endorphin) may play a role in modifying the pain threshold.

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KW - Dopamine

KW - Pain

KW - β-Endorphin

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ER -

The increased opiate action of β-endorphin in iron-deficient rats: The possible involvement of dopamine

Abstract

Bibliographical note

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Keywords

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