Abstract
Rats made nutritionally iron-deficient (ID) have been shown to have a lower brain non-haem. A selective diminution of the binding capacity of the D2-dopaminergic receptors alone was found among nutritionally iron-deficient rats. Peripherally administered β-endorphin significantly elevated the pain threshold only in the iron-deficient rats. Naloxone blocked the β-endorphin effect in ID rats. Morphine, as well as haloperidol, elevated the pain threshold in both the iron-deficient and the control rats but significantly more in the former group. No additive effects of combined treatment with β-endorphin and haloperidol on pain threshold were found. Other neuroleptics also elevated the pain threshold. A possible hypothesis is that dopamine (via β-endorphin) may play a role in modifying the pain threshold.
| Original language | English |
|---|---|
| Pages (from-to) | 245-251 |
| Number of pages | 7 |
| Journal | European Journal of Pharmacology |
| Volume | 104 |
| Issue number | 3-4 |
| DOIs | |
| State | Published - 17 Sep 1984 |
Bibliographical note
Funding Information:fl-Endorphin was generously donated by the N.I.H., U.S.A. This study was supported in part by research grants from the Bar-llan University Research Authority, by the Sapir Foundation and by the Rappaport Family Institute (Technion).
Funding
fl-Endorphin was generously donated by the N.I.H., U.S.A. This study was supported in part by research grants from the Bar-llan University Research Authority, by the Sapir Foundation and by the Rappaport Family Institute (Technion).
| Funders | Funder number |
|---|---|
| Bar-llan University Research Authority | |
| Rappaport Family Institute | |
| Sapir Foundation | |
| Technion-Israel Institute of Technology |
Keywords
- Circadian rhythm
- Dopamine
- Pain
- β-Endorphin