TY - JOUR
T1 - The importance of alternative splicing in the drug discovery process
AU - Levanon, Erez Y.
AU - Sorek, Rotem
PY - 2003
Y1 - 2003
N2 - The publication of the sequence of the human genome revealed that the gene count in humans is much lower than previously estimated. Although textbooks usually place the number at 100,000, it is currently estimated that the human genome contains no more than 30,000 protein-coding genes. How can the great complexity of human life be explained by this number, which is less than twice the number of genes in the primitive worm C. elegans? The answer probably lies in the recent discovery that about half of all human genes undergo alternative splicing. This paper reviews the broad implications of alternative splicing for the drug-discovery process.
AB - The publication of the sequence of the human genome revealed that the gene count in humans is much lower than previously estimated. Although textbooks usually place the number at 100,000, it is currently estimated that the human genome contains no more than 30,000 protein-coding genes. How can the great complexity of human life be explained by this number, which is less than twice the number of genes in the primitive worm C. elegans? The answer probably lies in the recent discovery that about half of all human genes undergo alternative splicing. This paper reviews the broad implications of alternative splicing for the drug-discovery process.
UR - http://www.scopus.com/inward/record.url?scp=3242893107&partnerID=8YFLogxK
U2 - 10.1016/s1477-3627(03)02322-5
DO - 10.1016/s1477-3627(03)02322-5
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AN - SCOPUS:3242893107
SN - 1741-8372
VL - 2
SP - 109
EP - 114
JO - Drug Discovery Today: TARGETS
JF - Drug Discovery Today: TARGETS
IS - 3
ER -