The impact of sub-clinical over-hydration on left ventricular mass in peritoneal dialysis patients

Kamal Hassan, Dunia Hassan, Alexander Shturman, Irina Rubinchik, Hassan Fadi, Hassan Shadi, Shaul Atar

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Objective: Left ventricular hypertrophy (LVH) represents a major predictor of the development of cardiovascular (CV) complications. Over-hydration (OH) is an important uremic risk factor associated with LVH and increased CV morbidity and mortality in peritoneal dialysis (PD) patients. In the present study we evaluated the prevalence of sub-clinical OH (SCOH) among PD patients and its effects on left ventricular mass (LVM). Methods: In this cross sectional study hydration status, blood pressure, glucose load, systemic inflammation and LVM were evaluated in 43 clinically stable patients on maintenance PD for 24-76 months. The hydration status was assessed by whole-body bio-impedance spectroscopy (BIS). Peripheral edema and any evidence of pulmonary congestion were considered clinical signs of OH. Results: OH ≥ 1.5 L was detected in 26 (60.5%) of the study participants; the OH in 19 (73.1%) of them was sub-clinical. Only 23.5% (4/17) of patients with OH < 1.5 L had LVH compared to 68.4% (13/19) of those with SCOH ≥ 1.5 L (P = 0.007). Compared to patients with OH < 1.5 L, patients with SCOH ≥ 1.5 L had higher levels of blood pressure, peritoneal glucose load, plasma brain natriuretic peptide, high sensitive C-reactive protein, interleukin-6 and LVMI; and lower levels of serum albumin (P < 0.001). No significant differences were found between patients with clinical OH or SCOH with OH ≥ 1.5 L. Conclusions: SCOH is highly prevalent among PD patients and may contribute to the development of LVH. Considering the poor prognosis associated with over-hydrated PD patients, periodic assessment of hydration status using accurate BIS is suggested.

Original languageEnglish
Pages (from-to)5890-5896
Number of pages7
JournalInternational Journal of Clinical and Experimental Medicine
Volume8
Issue number4
StatePublished - 30 Apr 2015

Bibliographical note

Publisher Copyright:
© 2015, E-Century Publishing Corporation. All rights reserved.

Keywords

  • Blood pressure
  • Fluid overload
  • Inflammation
  • Left ventricular mass
  • Over-hydration
  • Peritoneal dialysis

Fingerprint

Dive into the research topics of 'The impact of sub-clinical over-hydration on left ventricular mass in peritoneal dialysis patients'. Together they form a unique fingerprint.

Cite this