The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests: Impact of bariatric surgery on NAFLD

Carmit Netanel; David Goitein; Moshe Rubin; Yeruham Kleinbaum; Sima Katsherginsky; Hila Hermon; Keren Tsaraf; Irina Tachlytski; Amir Herman; Michal Safran; Ziv Ben-Ari

doi:10.1016/j.amjsurg.2020.11.045

The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests: Impact of bariatric surgery on NAFLD

Carmit Netanel
, David Goitein
, Moshe Rubin
, Yeruham Kleinbaum
, Sima Katsherginsky
, Hila Hermon
, Keren Tsaraf
, Irina Tachlytski
, Amir Herman
, Michal Safran
, Ziv Ben-Ari

Sheba Medical Center at Tel Hashomer
Tel Aviv University
Assuta Ashdod Hospital
Ben-Gurion University of the Negev

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Background: Nonalcoholic fatty liver disease (NAFLD) is common in bariatric surgery candidates. We evaluated the effect of sleeve gastrectomy (SG) on NAFLD using validated non-invasive measures. Methods: Patients with morbid obesity and NAFLD, planned for SG, were evaluated before and after surgery. Data collected included anthropometrics, biochemistry, adiponectin, SteatoTest™, NashTest™, FibroTest™, OWLiver® test and real-time ShearWave™ elastography (SWE). Results: Twenty-six subjects were included in the study, mean age 44.1 ± 4.8 years, 69.2% males. One year following SG, body mass index decreased significantly from 41.7 ± 4.8 kg/m² to 29.6 ± 4.5 kg/m². Concomitantly, significant improvements in triglycerides, ALT, diabetes markers and adiponectin were observed. Mean steatosis, as measured by SteatoTest™, was significantly improved. Steatohepatitis score measured by NashTest™ and OWLiver® significantly decreased. Mean fibrosis, as measured by SWE liver stiffness and FibroTest™, did not change over time. Conclusion: Steatosis and steatohepatitis are significantly improved by SG as measured by non-invasive measures.

Original language	English
Pages (from-to)	214-219
Number of pages	6
Journal	American Journal of Surgery
Volume	222
Issue number	1
DOIs	https://doi.org/10.1016/j.amjsurg.2020.11.045
State	Published - Jul 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.

Funding

The authors wish to thank OWL Metabolomics for their kind help with obtaining OWLiver® test results and interpretation.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bariatric surgery
Non-invasive tests
Nonalcoholic fatty liver disease
Nonalcoholic-steatohepatitis
Steatosis

Access to Document

10.1016/j.amjsurg.2020.11.045

Cite this

Netanel, C., Goitein, D., Rubin, M., Kleinbaum, Y., Katsherginsky, S., Hermon, H., Tsaraf, K., Tachlytski, I., Herman, A., Safran, M., & Ben-Ari, Z. (2021). The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests: Impact of bariatric surgery on NAFLD. American Journal of Surgery, 222(1), 214-219. https://doi.org/10.1016/j.amjsurg.2020.11.045

@article{47d4c8df11254f2c9014c46fb8c39dac,

title = "The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests: Impact of bariatric surgery on NAFLD",

abstract = "Background: Nonalcoholic fatty liver disease (NAFLD) is common in bariatric surgery candidates. We evaluated the effect of sleeve gastrectomy (SG) on NAFLD using validated non-invasive measures. Methods: Patients with morbid obesity and NAFLD, planned for SG, were evaluated before and after surgery. Data collected included anthropometrics, biochemistry, adiponectin, SteatoTest{\texttrademark}, NashTest{\texttrademark}, FibroTest{\texttrademark}, OWLiver{\textregistered} test and real-time ShearWave{\texttrademark} elastography (SWE). Results: Twenty-six subjects were included in the study, mean age 44.1 ± 4.8 years, 69.2\% males. One year following SG, body mass index decreased significantly from 41.7 ± 4.8 kg/m2 to 29.6 ± 4.5 kg/m2. Concomitantly, significant improvements in triglycerides, ALT, diabetes markers and adiponectin were observed. Mean steatosis, as measured by SteatoTest{\texttrademark}, was significantly improved. Steatohepatitis score measured by NashTest{\texttrademark} and OWLiver{\textregistered} significantly decreased. Mean fibrosis, as measured by SWE liver stiffness and FibroTest{\texttrademark}, did not change over time. Conclusion: Steatosis and steatohepatitis are significantly improved by SG as measured by non-invasive measures.",

keywords = "Bariatric surgery, Non-invasive tests, Nonalcoholic fatty liver disease, Nonalcoholic-steatohepatitis, Steatosis",

author = "Carmit Netanel and David Goitein and Moshe Rubin and Yeruham Kleinbaum and Sima Katsherginsky and Hila Hermon and Keren Tsaraf and Irina Tachlytski and Amir Herman and Michal Safran and Ziv Ben-Ari",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2021",

month = jul,

doi = "10.1016/j.amjsurg.2020.11.045",

language = "אנגלית",

volume = "222",

pages = "214--219",

journal = "American Journal of Surgery",

issn = "0002-9610",

publisher = "Elsevier Inc.",

number = "1",

}

Netanel, C, Goitein, D, Rubin, M, Kleinbaum, Y, Katsherginsky, S, Hermon, H, Tsaraf, K, Tachlytski, I, Herman, A, Safran, M & Ben-Ari, Z 2021, 'The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests: Impact of bariatric surgery on NAFLD', American Journal of Surgery, vol. 222, no. 1, pp. 214-219. https://doi.org/10.1016/j.amjsurg.2020.11.045

TY - JOUR

T1 - The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests

T2 - Impact of bariatric surgery on NAFLD

AU - Netanel, Carmit

AU - Goitein, David

AU - Rubin, Moshe

AU - Kleinbaum, Yeruham

AU - Katsherginsky, Sima

AU - Hermon, Hila

AU - Tsaraf, Keren

AU - Tachlytski, Irina

AU - Herman, Amir

AU - Safran, Michal

AU - Ben-Ari, Ziv

PY - 2021/7

Y1 - 2021/7

N2 - Background: Nonalcoholic fatty liver disease (NAFLD) is common in bariatric surgery candidates. We evaluated the effect of sleeve gastrectomy (SG) on NAFLD using validated non-invasive measures. Methods: Patients with morbid obesity and NAFLD, planned for SG, were evaluated before and after surgery. Data collected included anthropometrics, biochemistry, adiponectin, SteatoTest™, NashTest™, FibroTest™, OWLiver® test and real-time ShearWave™ elastography (SWE). Results: Twenty-six subjects were included in the study, mean age 44.1 ± 4.8 years, 69.2% males. One year following SG, body mass index decreased significantly from 41.7 ± 4.8 kg/m2 to 29.6 ± 4.5 kg/m2. Concomitantly, significant improvements in triglycerides, ALT, diabetes markers and adiponectin were observed. Mean steatosis, as measured by SteatoTest™, was significantly improved. Steatohepatitis score measured by NashTest™ and OWLiver® significantly decreased. Mean fibrosis, as measured by SWE liver stiffness and FibroTest™, did not change over time. Conclusion: Steatosis and steatohepatitis are significantly improved by SG as measured by non-invasive measures.

AB - Background: Nonalcoholic fatty liver disease (NAFLD) is common in bariatric surgery candidates. We evaluated the effect of sleeve gastrectomy (SG) on NAFLD using validated non-invasive measures. Methods: Patients with morbid obesity and NAFLD, planned for SG, were evaluated before and after surgery. Data collected included anthropometrics, biochemistry, adiponectin, SteatoTest™, NashTest™, FibroTest™, OWLiver® test and real-time ShearWave™ elastography (SWE). Results: Twenty-six subjects were included in the study, mean age 44.1 ± 4.8 years, 69.2% males. One year following SG, body mass index decreased significantly from 41.7 ± 4.8 kg/m2 to 29.6 ± 4.5 kg/m2. Concomitantly, significant improvements in triglycerides, ALT, diabetes markers and adiponectin were observed. Mean steatosis, as measured by SteatoTest™, was significantly improved. Steatohepatitis score measured by NashTest™ and OWLiver® significantly decreased. Mean fibrosis, as measured by SWE liver stiffness and FibroTest™, did not change over time. Conclusion: Steatosis and steatohepatitis are significantly improved by SG as measured by non-invasive measures.

KW - Bariatric surgery

KW - Non-invasive tests

KW - Nonalcoholic fatty liver disease

KW - Nonalcoholic-steatohepatitis

KW - Steatosis

UR - https://www.scopus.com/pages/publications/85097450641

U2 - 10.1016/j.amjsurg.2020.11.045

DO - 10.1016/j.amjsurg.2020.11.045

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 33309037

AN - SCOPUS:85097450641

SN - 0002-9610

VL - 222

SP - 214

EP - 219

JO - American Journal of Surgery

JF - American Journal of Surgery

IS - 1

ER -

The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests: Impact of bariatric surgery on NAFLD

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this