The Impact of a Positive Biofire® FilmArray® Gastrointestinal Panel Result on Clinical Management and Outcomes

David Carmon, Hanan Rohana, Maya Azrad, Avi Peretz

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The gold standard diagnostic method for gastrointestinal infections is stool culture, which has limited sensitivity and long turnaround time. Infection diagnosis recently shifted to syndrome-based panel assays. This study employed the FilmArray® Gastrointestinal Panel, which detects 22 pathogens simultaneously, to investigate gastrointestinal infection and pathogen distribution in 91 stool samples of patients hospitalized at the Tzafon Medical Center, Israel, during 2020, and to compare the clinical and demographic data of negative vs. positive samples. Among the 61 positive samples (67%), the most common pathogen was Campylobacter (34.4%). Positive test results were associated with a slightly younger patient age (p = 0.012), significantly higher post-diagnosis use of antibiotics (63.9% vs. 36.7%; p = 0.014), and shorter length of stay and time to discharge (p = 0.035, p = 0.003, respectively) than negative test results. To conclude, the FilmArray® Gastrointestinal Panel enabled the early identification of causative infectious agents and enhanced clinical management and outcomes.

Original languageEnglish
Article number1094
JournalDiagnostics
Volume13
Issue number6
DOIs
StatePublished - 14 Mar 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Keywords

  • FilmArray Gastrointestinal Panel
  • clinical management and outcomes
  • gastrointestinal infections
  • pathogen distribution
  • positive result

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