The Immunological Synapse Balances T Cell Receptor Signaling and Degradation

Kyeong Hee Lee; Aaron R. Dinner; Chun Tu; Gabriele Campi; Subhadip Raychaudhuri; Rajat Varma; Tasha N. Sims; W. Richard Burack; Hui Wu; Julia Wang; Osami Kanagawa; Mary Markiewicz; Paul M. Allen; Michael L. Dustin; Arup K. Chakraborty; Andrey S. Shaw

doi:10.1126/science.1086507

The Immunological Synapse Balances T Cell Receptor Signaling and Degradation

Kyeong Hee Lee, Aaron R. Dinner, Chun Tu, Gabriele Campi, Subhadip Raychaudhuri, Rajat Varma, Tasha N. Sims, W. Richard Burack, Hui Wu, Julia Wang, Osami Kanagawa, Mary Markiewicz, Paul M. Allen, Michael L. Dustin, Arup K. Chakraborty, Andrey S. Shaw

Research output: Contribution to journal › Article › peer-review

471 Scopus citations

Abstract

The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals.

Original language	English
Pages (from-to)	1218-1222
Number of pages	5
Journal	Science
Volume	302
Issue number	5648
DOIs	https://doi.org/10.1126/science.1086507
State	Published - 14 Nov 2003
Externally published	Yes

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Lee, K. H., Dinner, A. R., Tu, C., Campi, G., Raychaudhuri, S., Varma, R., Sims, T. N., Burack, W. R., Wu, H., Wang, J., Kanagawa, O., Markiewicz, M., Allen, P. M., Dustin, M. L., Chakraborty, A. K., & Shaw, A. S. (2003). The Immunological Synapse Balances T Cell Receptor Signaling and Degradation. Science, 302(5648), 1218-1222. https://doi.org/10.1126/science.1086507

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abstract = "The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals.",

author = "Lee, {Kyeong Hee} and Dinner, {Aaron R.} and Chun Tu and Gabriele Campi and Subhadip Raychaudhuri and Rajat Varma and Sims, {Tasha N.} and Burack, {W. Richard} and Hui Wu and Julia Wang and Osami Kanagawa and Mary Markiewicz and Allen, {Paul M.} and Dustin, {Michael L.} and Chakraborty, {Arup K.} and Shaw, {Andrey S.}",

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AU - Lee, Kyeong Hee

AU - Dinner, Aaron R.

AU - Tu, Chun

AU - Campi, Gabriele

AU - Raychaudhuri, Subhadip

AU - Varma, Rajat

AU - Sims, Tasha N.

AU - Burack, W. Richard

AU - Wu, Hui

AU - Wang, Julia

AU - Kanagawa, Osami

AU - Markiewicz, Mary

AU - Allen, Paul M.

AU - Dustin, Michael L.

AU - Chakraborty, Arup K.

AU - Shaw, Andrey S.

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AB - The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals.

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The Immunological Synapse Balances T Cell Receptor Signaling and Degradation

Abstract

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