The Humoral Response of Patients With Cancer to Breakthrough COVID-19 Infection or the Fourth BNT162b2 Vaccine Dose

Idan Cohen, Salvatore Campisi-Pfinto, Orit Rozenberg, Raul Colodner, Gil Bar-Sela

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Since January 2022 in Israel, high-risk populations with underlying health conditions were advised to receive a fourth dose of the BNT162b2 vaccine (Pfizer-BioNTech) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We monitored vaccine-induced immunity among oncology patients undergoing systemic anti-cancer therapy before and after the 4th-BNT162b2-dose. Three groups of patients were included in the study: those who received 3rd-BNT162b2-dose and had no breakthrough infection (control), those who received 3rd-BNT162b2- dose and had the breakthrough infection, and those who received the 4th-BNT162b2-dose and had no breakthrough infection. Anti-SARS-CoV-2 immunoglobulin-G (IgG) levels of the control group exhibited a rapid decrease over time, whereas IgG titers of patients with breakthroughinfections or patients vaccinated with the 4th-BNT162b2-dose were considerably elevated, consistent with the capacity of the second booster to induce anti-SARS-CoV-2 IgG levels. Additionally, oncology patients' humoral immune response was significantly greater after breakthroughinfection than in response to the 4th dose of BNT162b2.

Original languageEnglish
Pages (from-to)e225-e227
JournalOncologist
Volume28
Issue number4
DOIs
StatePublished - 6 Apr 2023
Externally publishedYes

Bibliographical note

Publisher Copyright:
© The Author(s) 2023.

Keywords

  • BNT162b2 vaccine
  • SARS-CoV-2
  • cancer patient

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