The highly synergistic, broad spectrum, antibacterial activity of organic acids and transition metals

Daniel Zhitnitsky, Jessica Rose, Oded Lewinson

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

For millennia, transition metals have been exploited to inhibit bacterial growth. We report here the potentiation of the anti-bacterial activity of transition metals by organic acids. Strong synergy between low, non-toxic concentrations of transition metals and organic acids was observed with up to ∼1000-fold higher inhibitory effect on bacterial growth. We show that organic acids shuttle transition metals through the permeability barrier of the bacterial membrane, leading to increased influx of transition metals into bacterial cells. We demonstrate that this synergy can be effectively used to inhibit the growth of a broad range of plant and human bacterial pathogens, and suggest that a revision of food preservation and crop protection strategies may be in order. These findings bear significant biomedical, agricultural, financial and environmental opportunities.

Original languageEnglish
Article number44554
JournalScientific Reports
Volume7
DOIs
StatePublished - 15 Mar 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© The Author(s) 2017.

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