The hidden (degron) truth behind the degradation of DHFR disease-associated variants

Itay Koren

doi:10.1016/j.str.2022.08.003

The hidden (degron) truth behind the degradation of DHFR disease-associated variants

Itay Koren

The Mina and Everard Goodman Faculty of Life Sciences - at Bar-Ilan University

Research output: Contribution to journal › Comment/debate

Abstract

In this issue of Structure, Kampmeyer et al. provide detailed mechanistic insights into how structural changes in disease-associated dihydrofolate reductase (DHFR) missense variants affect their cellular protein abundance and discuss implications for hereditary megaloblastic anemia disease.

Original language	English
Pages (from-to)	1219-1221
Number of pages	3
Journal	Structure
Volume	30
Issue number	9
DOIs	https://doi.org/10.1016/j.str.2022.08.003
State	Published - 1 Sep 2022

Bibliographical note

Publisher Copyright:
© 2022

Funding

The work in my laboratory on PQC is supported by European Research Council ( ERC-2020-STG 947709 ) and Israel Science Foundation (ISF) ( 2380/21 , 3096/21 ). Figure 1 was created with BioRender.com .

Funders	Funder number
European Commission	ERC-2020-STG 947709
Israel Science Foundation	3096/21, 2380/21

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10.1016/j.str.2022.08.003

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The hidden (degron) truth behind the degradation of DHFR disease-associated variants

Abstract

Bibliographical note

Funding

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