The gut-kidney axis in chronic renal failure: A new potential target for therapy

Tawfik Khoury, Keren Tzukert, Roy Abel, Ayman Abu Rmeileh, Ronen Levi, Yaron Ilan

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


Evidence is accumulating to consider the gut microbiome as a central player in the gut-kidney axis. Microbiome products, such as advanced glycation end products, phenols, and indoles, are absorbed into the circulation but are cleared by normal-functioning kidneys. These products then become toxic and contribute to the uremic load and to the progression of chronic kidney failure. In this review, we discuss the gut-kidney interaction under the state of chronic kidney failure as well as the potential mechanisms by which a change in the gut flora (termed gut dysbiosis) in chronic kidney disease (CKD) exacerbates uremia and leads to further progression of CKD and inflammation. Finally, the potential therapeutic interventions to target the gut microbiome in CKD are discussed.

Original languageEnglish
Pages (from-to)323-334
Number of pages12
JournalHemodialysis International
Issue number3
StatePublished - Jul 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 International Society for Hemodialysis


  • Gut microbiome
  • bacterial translocation
  • chronic renal failure


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