TY - JOUR
T1 - The gut-kidney axis in chronic renal failure
T2 - A new potential target for therapy
AU - Khoury, Tawfik
AU - Tzukert, Keren
AU - Abel, Roy
AU - Abu Rmeileh, Ayman
AU - Levi, Ronen
AU - Ilan, Yaron
N1 - Publisher Copyright:
© 2016 International Society for Hemodialysis
PY - 2017/7
Y1 - 2017/7
N2 - Evidence is accumulating to consider the gut microbiome as a central player in the gut-kidney axis. Microbiome products, such as advanced glycation end products, phenols, and indoles, are absorbed into the circulation but are cleared by normal-functioning kidneys. These products then become toxic and contribute to the uremic load and to the progression of chronic kidney failure. In this review, we discuss the gut-kidney interaction under the state of chronic kidney failure as well as the potential mechanisms by which a change in the gut flora (termed gut dysbiosis) in chronic kidney disease (CKD) exacerbates uremia and leads to further progression of CKD and inflammation. Finally, the potential therapeutic interventions to target the gut microbiome in CKD are discussed.
AB - Evidence is accumulating to consider the gut microbiome as a central player in the gut-kidney axis. Microbiome products, such as advanced glycation end products, phenols, and indoles, are absorbed into the circulation but are cleared by normal-functioning kidneys. These products then become toxic and contribute to the uremic load and to the progression of chronic kidney failure. In this review, we discuss the gut-kidney interaction under the state of chronic kidney failure as well as the potential mechanisms by which a change in the gut flora (termed gut dysbiosis) in chronic kidney disease (CKD) exacerbates uremia and leads to further progression of CKD and inflammation. Finally, the potential therapeutic interventions to target the gut microbiome in CKD are discussed.
KW - Gut microbiome
KW - bacterial translocation
KW - chronic renal failure
UR - http://www.scopus.com/inward/record.url?scp=84993949725&partnerID=8YFLogxK
U2 - 10.1111/hdi.12486
DO - 10.1111/hdi.12486
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C2 - 27634464
AN - SCOPUS:84993949725
SN - 1492-7535
VL - 21
SP - 323
EP - 334
JO - Hemodialysis International
JF - Hemodialysis International
IS - 3
ER -