The growing incidence of Bullous pemphigoid: Overview and potential explanations

Khalaf Kridin; Ralf J. Ludwig

doi:10.3389/fmed.2018.00220

The growing incidence of Bullous pemphigoid: Overview and potential explanations

Khalaf Kridin
, Ralf J. Ludwig

Research output: Contribution to journal › Review article › peer-review

202 Scopus citations

Abstract

Bullous pemphigoid (BP) is the most common type of subepidermal autoimmune bullous diseases. BP characteristically affects the elderly and is seen mainly in patients older than 70 years. While the annual incidence of BP has been estimated to be between 2.4 and 23 cases per million in the general population, it rises exponentially to 190-312 cases per million in individuals older than 80 years. In addition, a growing body of evidence reports a remarkable trend of increased incidence of BP, showing a 1.9- to 4.3-fold rise over the past two decades. This demonstrable increase warrants a higher awareness of the increased risk to develop BP. This review summarizes the current understanding of the epidemiological features of BP and sheds light on the putative explanations for its growing incidence.

Original language	English
Article number	220
Journal	Frontiers in Medicine
Volume	5
Issue number	AUG
DOIs	https://doi.org/10.3389/fmed.2018.00220
State	Published - 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 Kridin and Ludwig.

Funding

The study was supported by the Excellence Cluster Inflammation at Interfaces (EXC 306/2), and the Clinical Research Unit Pemphigoid Diseases (KFO 303/1) all from the Deutsche Forschungsgemeinschaft.

Funders	Funder number
Excellence Cluster Inflammation at Interfaces	EXC 306/2, KFO 303/1
Deutsche Forschungsgemeinschaft

Keywords

Bullous pemphigoid
DPP-4 inhibitors
Epidemiology
Explanation
Incidence
Longevity
Review of literature

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10.3389/fmed.2018.00220

Cite this

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title = "The growing incidence of Bullous pemphigoid: Overview and potential explanations",

abstract = "Bullous pemphigoid (BP) is the most common type of subepidermal autoimmune bullous diseases. BP characteristically affects the elderly and is seen mainly in patients older than 70 years. While the annual incidence of BP has been estimated to be between 2.4 and 23 cases per million in the general population, it rises exponentially to 190-312 cases per million in individuals older than 80 years. In addition, a growing body of evidence reports a remarkable trend of increased incidence of BP, showing a 1.9- to 4.3-fold rise over the past two decades. This demonstrable increase warrants a higher awareness of the increased risk to develop BP. This review summarizes the current understanding of the epidemiological features of BP and sheds light on the putative explanations for its growing incidence.",

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The growing incidence of Bullous pemphigoid: Overview and potential explanations

Abstract

Bibliographical note

Funding

Keywords

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