The genetics of bone mass and susceptibility to bone diseases

David Karasik, Fernando Rivadeneira, Mark L. Johnson

Research output: Contribution to journalReview articlepeer-review

62 Scopus citations

Abstract

Osteoporosis is characterized by low bone mass and an increased risk of fracture. Genetic factors, environmental factors and gene-environment interactions all contribute to a person's lifetime risk of developing an osteoporotic fracture. This Review summarizes key advances in understanding of the genetics of bone traits and their role in osteoporosis. Candidate-gene approaches dominated this field 20 years ago, but clinical and preclinical genetic studies published in the past 5 years generally utilize more-sophisticated and better-powered genome-wide association studies (GWAS). High-throughput DNA sequencing, large genomic databases and improved methods of data analysis have greatly accelerated the gene-discovery process. Linkage analyses of single-gene traits that segregate in families with extreme phenotypes have led to the elucidation of critical pathways controlling bone mass. For example, components of the Wnt-β-catenin signalling pathway have been validated (in both GWAS and functional studies) as contributing to various bone phenotypes. These notable advances in gene discovery suggest that the next decade will witness cataloguing of the hundreds of genes that influence bone mass and osteoporosis, which in turn will provide a roadmap for the development of new drugs that target diseases of low bone mass, including osteoporosis.

Original languageEnglish
Pages (from-to)323-334
Number of pages12
JournalNature reviews. Rheumatology
Volume12
Issue number6
DOIs
StatePublished - 24 May 2016

Bibliographical note

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© 2016 Macmillan Publishers Limited. All rights reserved.

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