The genetics and molecular structure of the Drosophila pair-rule gene odd Oz (odz)

Anna Levine; Devorah Gartenberg; Rivka Yakov; Yael Lieberman; Ofra Budai-Hadrian; Ayelet Bashan-Ahrend; Ron Wides

doi:10.1016/s0378-1119(97)00375-2

The genetics and molecular structure of the Drosophila pair-rule gene odd Oz (odz)

Anna Levine, Devorah Gartenberg, Rivka Yakov, Yael Lieberman, Ofra Budai-Hadrian, Ayelet Bashan-Ahrend, Ron Wides

The Mina and Everard Goodman Faculty of Life Sciences - at Bar-Ilan University

Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Null alleles of the odz pair-rule gene have been generated as small Deficiency chromosome mutations. The true null phenotype of odz in segmentation is now seen to be very similar to that originally characterized, with each odd segment removed. No other previously isolated mutations in the genomic region proved allelic to odz. The generated Deficiencies covering the odz locus and immediately surrounding regions do not cover any other gene tested from that region. The entire odz gene has been cloned and mapped, and represents more than 120 kb of genomic DNA. The gene has been sequenced, except for two very large introns. Analysis of the upstream control region of the gene indicates the presence of a large number of putative binding sites for transcription factors that direct relevant developmentally regulated gene transcription.

Original language	English
Pages (from-to)	59-74
Number of pages	16
Journal	Gene
Volume	200
Issue number	1-2
DOIs	https://doi.org/10.1016/s0378-1119(97)00375-2
State	Published - 24 Oct 1997

Bibliographical note

Funding Information:
We thank Tevie Mehlman for sequencing expertise. For helpful discussions, we thank Benny Shilo, the members of his lab, and Talila Volk. R.J.W. has been an Israel Cancer Research Fund fellow. R.J.W. and A.L. have both received support from the Israel Ministry of Absorption. Portions of this project have been supported by the Israel Academy of Science. Drosophila stocks were kindly provided by the Bloomington and Bowling Green stock centers, E. Wieschaus, A. Spradling, J. Kennison, S. Tiong, C. Nüsslein-Volhard, A. Shearn, T. Volk, and B. Shilo.

Funding

We thank Tevie Mehlman for sequencing expertise. For helpful discussions, we thank Benny Shilo, the members of his lab, and Talila Volk. R.J.W. has been an Israel Cancer Research Fund fellow. R.J.W. and A.L. have both received support from the Israel Ministry of Absorption. Portions of this project have been supported by the Israel Academy of Science. Drosophila stocks were kindly provided by the Bloomington and Bowling Green stock centers, E. Wieschaus, A. Spradling, J. Kennison, S. Tiong, C. Nüsslein-Volhard, A. Shearn, T. Volk, and B. Shilo.

Funders	Funder number
Israel Academy of Science

Keywords

Genomic sequence
Pattern formation
Segmentation gene
Tyrosine kinase substrate

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10.1016/s0378-1119(97)00375-2

Cite this

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title = "The genetics and molecular structure of the Drosophila pair-rule gene odd Oz (odz)",

abstract = "Null alleles of the odz pair-rule gene have been generated as small Deficiency chromosome mutations. The true null phenotype of odz in segmentation is now seen to be very similar to that originally characterized, with each odd segment removed. No other previously isolated mutations in the genomic region proved allelic to odz. The generated Deficiencies covering the odz locus and immediately surrounding regions do not cover any other gene tested from that region. The entire odz gene has been cloned and mapped, and represents more than 120 kb of genomic DNA. The gene has been sequenced, except for two very large introns. Analysis of the upstream control region of the gene indicates the presence of a large number of putative binding sites for transcription factors that direct relevant developmentally regulated gene transcription.",

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The genetics and molecular structure of the Drosophila pair-rule gene odd Oz (odz)

Abstract

Bibliographical note

Funding

Keywords

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