TY - JOUR
T1 - The future of prognostic factors in outcome prediction for patients with cancer
AU - Fielding, L. Peter
AU - Fenoglio‐Preiser, Cecilia M.
AU - Freedman, Laurence S.
PY - 1992/11/1
Y1 - 1992/11/1
N2 - The anatomic description of the extent of tumor spread (tumor staging) assists clinical management, facilitates communication among physicians, is an essential part of randomized controlled trials, and may help in the counseling patients and their families. However, in recent years, additional “prognostic factors” have been defined, many of which assess or reflect the biologic behavior of malignant neoplasms. Other measures of tumor biochemistry address the natural history of neoplastic development and often are included in a discussion of new prognostic factors. This review article summarizes current knowledge and thinking related to tumor prognostic factors in four areas by providing: (1) a definition and principles of anatomic spread of tumor (staging) and some suggestions for improvement, (2) a description of some examples of additional factors of prognostic significance, (3) some statistical methods to evaluate prognostic factors, and (4) an examination of the possible future of summary statements of outcome (i.e., prognostic indexes). Cancer 1992; 70:2367‐2377.
AB - The anatomic description of the extent of tumor spread (tumor staging) assists clinical management, facilitates communication among physicians, is an essential part of randomized controlled trials, and may help in the counseling patients and their families. However, in recent years, additional “prognostic factors” have been defined, many of which assess or reflect the biologic behavior of malignant neoplasms. Other measures of tumor biochemistry address the natural history of neoplastic development and often are included in a discussion of new prognostic factors. This review article summarizes current knowledge and thinking related to tumor prognostic factors in four areas by providing: (1) a definition and principles of anatomic spread of tumor (staging) and some suggestions for improvement, (2) a description of some examples of additional factors of prognostic significance, (3) some statistical methods to evaluate prognostic factors, and (4) an examination of the possible future of summary statements of outcome (i.e., prognostic indexes). Cancer 1992; 70:2367‐2377.
KW - cancer
KW - flow cytometry
KW - molecular markers
KW - outcome
KW - prognostic factors
KW - prognostic indexes
KW - staging
KW - tumor immunity
UR - http://www.scopus.com/inward/record.url?scp=0026668490&partnerID=8YFLogxK
U2 - 10.1002/1097-0142(19921101)70:9<2367::AID-CNCR2820700927>3.0.CO;2-B
DO - 10.1002/1097-0142(19921101)70:9<2367::AID-CNCR2820700927>3.0.CO;2-B
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C2 - 1394064
AN - SCOPUS:0026668490
SN - 0008-543X
VL - 70
SP - 2367
EP - 2377
JO - Cancer
JF - Cancer
IS - 9
ER -
