The functional connectivity between the locust leg pattern generators and the subesophageal ganglion higher motor center

Daniel Knebel; Jan Rillich; Leonard Nadler; Hans Joachim Pflüger; Amir Ayali

doi:10.1016/j.neulet.2018.10.060

The functional connectivity between the locust leg pattern generators and the subesophageal ganglion higher motor center

Daniel Knebel, Jan Rillich, Leonard Nadler, Hans Joachim Pflüger, Amir Ayali

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Higher motor centers and central pattern generators (CPGs) interact in the control of coordinated leg movements during locomotion throughout the animal kingdom. The subesophageal ganglion (SEG) is one of the insect head ganglia reported to have a role in the control of walking behavior. Here we explored the functional relations between the SEG and the thoracic leg CPGs in the desert locust. Backfill staining revealed about 300 SEG descending interneurons (DINs) altogether. Recordings from an in-vitro isolated chain of thoracic ganglia, with intact or severed connections to the SEG, during pharmacological activation were used to determine how the SEG affects the centrally generated motor output to the legs. The SEG was demonstrated to both activate leg CPGs and synchronize their bilateral activity. The role of the SEG in insect locomotion is discussed in light of these findings.

Original language	English
Pages (from-to)	77-82
Number of pages	6
Journal	Neuroscience Letters
Volume	692
DOIs	https://doi.org/10.1016/j.neulet.2018.10.060
State	Published - 23 Jan 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 Elsevier B.V.

Funding

This work was partially supported by DAAD travel scholarships (to DK) and, in its final stages, by the German Research Council (DFG; Grant RI 2728/2-1). H-J P gratefully acknowledges the support by the DFG (FOR 1363, Pf128/30-1 and PF128/32-1) and the receipt of a Berlin NaFoeG-stipend to LN. This work was partially supported by DAAD travel scholarships (to DK) and, in its final stages, by the German Research Council (DFG; Grant RI 2728/2-1 ). H-J P gratefully acknowledges the support by the DFG (FOR 1363, Pf128/30-1 and PF128/32-1) and the receipt of a Berlin NaFoeG-stipend to LN.

Funders	Funder number
German Research Council
California Department of Fish and Wildlife
Deutscher Akademischer Austauschdienst
Deutsche Forschungsgemeinschaft	FOR 1363, RI 2728/2-1, PF128/32-1, Pf128/30-1

Keywords

Central pattern generator (CPG)
Insect
Intersegmental coordination
Locomotion
Locust
Subesophageal ganglion (SEG)

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10.1016/j.neulet.2018.10.060

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title = "The functional connectivity between the locust leg pattern generators and the subesophageal ganglion higher motor center",

abstract = "Higher motor centers and central pattern generators (CPGs) interact in the control of coordinated leg movements during locomotion throughout the animal kingdom. The subesophageal ganglion (SEG) is one of the insect head ganglia reported to have a role in the control of walking behavior. Here we explored the functional relations between the SEG and the thoracic leg CPGs in the desert locust. Backfill staining revealed about 300 SEG descending interneurons (DINs) altogether. Recordings from an in-vitro isolated chain of thoracic ganglia, with intact or severed connections to the SEG, during pharmacological activation were used to determine how the SEG affects the centrally generated motor output to the legs. The SEG was demonstrated to both activate leg CPGs and synchronize their bilateral activity. The role of the SEG in insect locomotion is discussed in light of these findings.",

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The functional connectivity between the locust leg pattern generators and the subesophageal ganglion higher motor center

Abstract

Bibliographical note

Funding

Keywords

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