The Final Stereogenic Unit of [2]Rotaxanes: Type 2 Geometric Isomers

Andrea Savoini, Peter R. Gallagher, Abed Saady, Stephen M. Goldup

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Mechanical stereochemistry arises when the interlocking of stereochemically trivial covalent subcomponents results in a stereochemically complex object. Although this general concept was identified in 1961, the stereochemical description of these molecules is still under development to the extent that new forms of mechanical stereochemistry are still being identified. Here, we present a simple analysis of rotaxane and catenane stereochemistry that allowed us to identify the final missing simple mechanical stereogenic unit, an overlooked form of rotaxane geometric isomerism, and demonstrate its stereoselective synthesis.

Original languageEnglish
Pages (from-to)8472-8479
Number of pages8
JournalJournal of the American Chemical Society
Volume146
Issue number12
DOIs
StatePublished - 27 Mar 2024
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2024 The Authors. Published by American Chemical Society

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