The facilitative effects of α-MSH and melanin on learning, thermoregulation, and pain in neonatal MSG-treated rats

Shlomo Yehuda; Raphael L. Carasso; David I. Mostofsky

doi:10.1016/0196-9781(91)90085-4

The facilitative effects of α-MSH and melanin on learning, thermoregulation, and pain in neonatal MSG-treated rats

Shlomo Yehuda, Raphael L. Carasso, David I. Mostofsky

Department of Psychology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Administration of monosodium glutamate (MSG) in the neonatal period renders the rat to be α-MSH deficient later in life. In this study rats received MSG in their neonatal period and were examined at the age of 60 days. α-MSH caused hypothermia, potentiated induced hypothermia, blocked paradoxical behavioral thermoregulation, improved performance in the Morris water tank, but had no effect on pain threshold. Melanin only caused an increase in pain threshold. It is suggested that the differential effect of α-MSH and melanin is governed by the dopaminergic system.

Original language	English
Pages (from-to)	465-469
Number of pages	5
Journal	Peptides
Volume	12
Issue number	3
DOIs	https://doi.org/10.1016/0196-9781(91)90085-4
State	Published - 1991

Keywords

Learning
MIF-1
MSG
Melanin
Pain
Paradoxical behavioral thermoregulation
Thermoregulation
α-MSH

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10.1016/0196-9781(91)90085-4

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AU - Carasso, Raphael L.

AU - Mostofsky, David I.

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AB - Administration of monosodium glutamate (MSG) in the neonatal period renders the rat to be α-MSH deficient later in life. In this study rats received MSG in their neonatal period and were examined at the age of 60 days. α-MSH caused hypothermia, potentiated induced hypothermia, blocked paradoxical behavioral thermoregulation, improved performance in the Morris water tank, but had no effect on pain threshold. Melanin only caused an increase in pain threshold. It is suggested that the differential effect of α-MSH and melanin is governed by the dopaminergic system.

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The facilitative effects of α-MSH and melanin on learning, thermoregulation, and pain in neonatal MSG-treated rats

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