The facilitative effects of α-MSH and melanin on learning, thermoregulation, and pain in neonatal MSG-treated rats

Shlomo Yehuda, Raphael L. Carasso, David I. Mostofsky

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Administration of monosodium glutamate (MSG) in the neonatal period renders the rat to be α-MSH deficient later in life. In this study rats received MSG in their neonatal period and were examined at the age of 60 days. α-MSH caused hypothermia, potentiated induced hypothermia, blocked paradoxical behavioral thermoregulation, improved performance in the Morris water tank, but had no effect on pain threshold. Melanin only caused an increase in pain threshold. It is suggested that the differential effect of α-MSH and melanin is governed by the dopaminergic system.

Original languageEnglish
Pages (from-to)465-469
Number of pages5
JournalPeptides
Volume12
Issue number3
DOIs
StatePublished - 1991

Keywords

  • Learning
  • MIF-1
  • MSG
  • Melanin
  • Pain
  • Paradoxical behavioral thermoregulation
  • Thermoregulation
  • α-MSH

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