The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research

The Extracellular RNA Communication Consortium

doi:10.1016/j.cell.2019.03.023

The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research

The Extracellular RNA Communication Consortium

Bar-Ilan University - Azrieli Faculty of Medicine

Research output: Contribution to journal › Review article › peer-review

152 Scopus citations

Abstract

The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles (EVs), can mediate intercellular communication and be utilized for clinical applications. Phase 1 of the ERCC focused on exRNA/EV biogenesis and function, discovery of exRNA biomarkers, development of exRNA/EV-based therapeutics, and construction of a robust set of reference exRNA profiles for a variety of biofluids. Here, we present progress by ERCC investigators in these areas, and we discuss collaborative projects directed at development of robust methods for EV/exRNA isolation and analysis and tools for sharing and computational analysis of exRNA profiling data. The Extracellular RNA Communication Consortium (ERCC) presents progress toward understanding the biology of extracellular RNAs and their use as biomarkers and therapeutics.

Original language	English
Pages (from-to)	231-242
Number of pages	12
Journal	Cell
Volume	177
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2019.03.023
State	Published - 4 Apr 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.

Funding

We acknowledge program leadership by members of the NIH Extracellular RNA Communication Workgroup, especially Kevin Howcroft, Danilo Tagle, John Satterlee, Patricia Labosky, Pothur Srinivas, Nic Johnston, Kayla Valdes, Lillian Kuo, Dena Procaccini, Dinah Singer, and Christopher Austin. We also acknowledge valuable feedback from the program’s External Scientific Panel members: Beverly Davidson, Tom Gingeras, Jan Lötvall, Janusz Rak, Gyongyi Szabo, and Kenneth Witwer. We would like to thank Elke Norwig-Eastaugh for her valuable contribution in organizing the ERCC investigator meetings. We thank Luc Laurent for creation of Figure 1 . All authors were supported by the NIH Common Fund Extracellular RNA Communication Program through the following grants: 1U01HL126493 , 1U01HL126494 , 1U01HL126495 , 1U01HL126496 , 1U01HL126497 , 1U01HL126499 , 1U19CA179512 , 1U19CA179513 , 1U19CA179514 , 1U19CA179563 , 1U19CA179564 , 1U54DA036134 , 1UH2TR000875 , 1UH2TR000880 , 1UH2TR000884 , 1UH2TR000888 , 1UH2TR000890 , 1UH2TR000891 , 1UH2TR000901 , 1UH2TR000902 , 1UH2TR000903 , 1UH2TR000906 , 1UH2TR000914 , 1UH2TR000918 , 1UH2TR000921 , 1UH2TR000923 , 1UH2TR000928 , 1UH2TR000931 , 1UH2TR000933 , 1UH2TR000943 . The views expressed in this article are solely those of the authors and may not necessarily reflect those of the NIH.

Funders

Funder number

National Institutes of Health

1UH2TR000906, 1UH2TR000928, 1UH2TR000903, 1UH2TR000884, 1UH2TR000901, 1UH2TR000923, 1UH2TR000902, 1UH2TR000888, 1UH2TR000921, 1UH2TR000943, 1U19CA179564, 1UH2TR000880, 1U19CA179563, 1U54DA036134, 1UH2TR000914, 1UH2TR000918, 1UH2TR000875, 1UH2TR000933, 1U01HL126495, 1U19CA179513, 1U01HL126496, 1U19CA179514, 1UH2TR000890, 1U01HL126497, 1U19CA179512, 1U01HL126493, 1UH2TR000891, 1U01HL126494, 1U01HL126499

National Center for Advancing Translational Sciences

UH2TR000931

Access to Document

10.1016/j.cell.2019.03.023

Cite this

@article{06be6c74315648359bc7990135725de7,

title = "The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research",

abstract = "The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles (EVs), can mediate intercellular communication and be utilized for clinical applications. Phase 1 of the ERCC focused on exRNA/EV biogenesis and function, discovery of exRNA biomarkers, development of exRNA/EV-based therapeutics, and construction of a robust set of reference exRNA profiles for a variety of biofluids. Here, we present progress by ERCC investigators in these areas, and we discuss collaborative projects directed at development of robust methods for EV/exRNA isolation and analysis and tools for sharing and computational analysis of exRNA profiling data. The Extracellular RNA Communication Consortium (ERCC) presents progress toward understanding the biology of extracellular RNAs and their use as biomarkers and therapeutics.",

author = "{The Extracellular RNA Communication Consortium} and Saumya Das and Abdel-Mageed, {Asim B.} and Catherine Adamidi and Adelson, {P. David} and Akat, {Kemal M.} and Eric Alsop and Ansel, {K. Mark} and Jorge Arango and Neil Aronin and Avsaroglu, {Seda Kilinc} and Azadeh Azizian and Leonora Balaj and Ben-Dov, {Iddo Z.} and Karl Bertram and Markus Bitzer and Robert Blelloch and Bogardus, {Kimberly A.} and Breakefield, {Xandra Owens} and Calin, {George A.} and Carter, {Bob S.} and Al Charest and Chen, {Clark C.} and Tanuja Chitnis and Coffey, {Robert J.} and Amanda Courtright-Lim and Amrita Datta and Peter DeHoff and Diacovo, {Thomas G.} and Erle, {David J.} and Alton Etheridge and Marc Ferrer and Franklin, {Jeffrey L.} and Freedman, {Jane E.} and Galas, {David J.} and Timur Galeev and Roopali Gandhi and Aitor Garcia and Vikas Ghai and Ghiran, {Ionita Calin} and Giraldez, {Maria D.} and Andrei Goga and Tasos Gogakos and Beatrice Goilav and Gould, {Stephen J.} and Peixuan Guo and Mihir Gupta and Fred Hochberg and Bo Huang and Matt Huentelman and Chaim Putterman",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = apr,

day = "4",

doi = "10.1016/j.cell.2019.03.023",

language = "אנגלית",

volume = "177",

pages = "231--242",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "2",

}

TY - JOUR

T1 - The Extracellular RNA Communication Consortium

T2 - Establishing Foundational Knowledge and Technologies for Extracellular RNA Research

AU - The Extracellular RNA Communication Consortium

AU - Das, Saumya

AU - Abdel-Mageed, Asim B.

AU - Adamidi, Catherine

AU - Adelson, P. David

AU - Akat, Kemal M.

AU - Alsop, Eric

AU - Ansel, K. Mark

AU - Arango, Jorge

AU - Aronin, Neil

AU - Avsaroglu, Seda Kilinc

AU - Azizian, Azadeh

AU - Balaj, Leonora

AU - Ben-Dov, Iddo Z.

AU - Bertram, Karl

AU - Bitzer, Markus

AU - Blelloch, Robert

AU - Bogardus, Kimberly A.

AU - Breakefield, Xandra Owens

AU - Calin, George A.

AU - Carter, Bob S.

AU - Charest, Al

AU - Chen, Clark C.

AU - Chitnis, Tanuja

AU - Coffey, Robert J.

AU - Courtright-Lim, Amanda

AU - Datta, Amrita

AU - DeHoff, Peter

AU - Diacovo, Thomas G.

AU - Erle, David J.

AU - Etheridge, Alton

AU - Ferrer, Marc

AU - Franklin, Jeffrey L.

AU - Freedman, Jane E.

AU - Galas, David J.

AU - Galeev, Timur

AU - Gandhi, Roopali

AU - Garcia, Aitor

AU - Ghai, Vikas

AU - Ghiran, Ionita Calin

AU - Giraldez, Maria D.

AU - Goga, Andrei

AU - Gogakos, Tasos

AU - Goilav, Beatrice

AU - Gould, Stephen J.

AU - Guo, Peixuan

AU - Gupta, Mihir

AU - Hochberg, Fred

AU - Huang, Bo

AU - Huentelman, Matt

AU - Putterman, Chaim

PY - 2019/4/4

Y1 - 2019/4/4

N2 - The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles (EVs), can mediate intercellular communication and be utilized for clinical applications. Phase 1 of the ERCC focused on exRNA/EV biogenesis and function, discovery of exRNA biomarkers, development of exRNA/EV-based therapeutics, and construction of a robust set of reference exRNA profiles for a variety of biofluids. Here, we present progress by ERCC investigators in these areas, and we discuss collaborative projects directed at development of robust methods for EV/exRNA isolation and analysis and tools for sharing and computational analysis of exRNA profiling data. The Extracellular RNA Communication Consortium (ERCC) presents progress toward understanding the biology of extracellular RNAs and their use as biomarkers and therapeutics.

AB - The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles (EVs), can mediate intercellular communication and be utilized for clinical applications. Phase 1 of the ERCC focused on exRNA/EV biogenesis and function, discovery of exRNA biomarkers, development of exRNA/EV-based therapeutics, and construction of a robust set of reference exRNA profiles for a variety of biofluids. Here, we present progress by ERCC investigators in these areas, and we discuss collaborative projects directed at development of robust methods for EV/exRNA isolation and analysis and tools for sharing and computational analysis of exRNA profiling data. The Extracellular RNA Communication Consortium (ERCC) presents progress toward understanding the biology of extracellular RNAs and their use as biomarkers and therapeutics.

UR - http://www.scopus.com/inward/record.url?scp=85063395528&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2019.03.023

DO - 10.1016/j.cell.2019.03.023

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???

C2 - 30951667

AN - SCOPUS:85063395528

SN - 0092-8674

VL - 177

SP - 231

EP - 242

JO - Cell

JF - Cell

IS - 2

ER -

The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research

Abstract

Bibliographical note

Funding

Access to Document

Other files and links

Fingerprint

Cite this